Tag Archives: PDA

Why doesn’t closing the PDA help preterm infants?

Posted on 12 December 2025 by Keith Barrington

I have been continuing to think about this issue, so will subject you all to some of my thoughts. The large RCTs of medication for closure of the PDA show no benefit, and some evidence of harms, but we all … Continue reading →

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Should we ever close the PDA?

Posted on 10 December 2025 by Keith Barrington

The latest large multicentre RCT has just been published. Laughon MM, et al. Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants. JAMA. 2025. In this trial, infants of 22 to 28 weeks GA were randomized at between … Continue reading →

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Is there any indication to close the PDA?

Posted on 26 January 2024 by Keith Barrington

Yet another trial of PDA treatment and attempted closure with a null result. Baby-OSCAR was a UK multi-center masked RCT of ibuprofen treatment of 23 to <29 week infants who were screened with echocardiogram within the first 72 hours of … Continue reading →

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Closing the PDA… or leaving it alone?

Posted on 20 October 2023 by Keith Barrington

Two new publications, in the Journal of Pediatrics, report trends in definitive closure of the PDA. This is a subject that I haven’t written about much on the blog, I wrote about the Beneductus trial last year, which was an … Continue reading →

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PAS 2018 No3: Should we TOLERATE the PDA?

Posted on 10 May 2018 by Keith Barrington

This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading →

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Paracetamol for the PDA? Maybe not, this time.

Posted on 15 May 2015 by Keith Barrington

Roofthooft DW, et al. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015:1-8. In contrast to the previous study that I blogged … Continue reading →

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Paracetamol for the PDA?

Posted on 26 April 2015 by Keith Barrington

EL-Khuffash A, et al. Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2015;100(3):F253-F6. (CoI statement: The authors of this paper are friends, colleagues and collaborators of mine), the … Continue reading →

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Reassuring Prophylactic Indomethacin Data

Posted on 28 October 2014 by Keith Barrington

One of Annie Janvier’s first research projects was a case control study of the influence of prophylactic indomethacin on intestinal perforations. Under my supervision she analyzed cases of spontaneous intestinal perforation (SIP), and we analyzed the influence of prophylactic indomethacin, … Continue reading →

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Can Paracetamol (acetaminophen) close the ductus arteriosus?

Posted on 29 September 2014 by Keith Barrington

A new publication by Afif El-Khuffash and his colleagues (El-Khuffash A et al. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res. 2014;76(3):238-44) describes a retrospective review of paracetamol use in newborn … Continue reading →

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Low Cardiac Output after PDA ligation

Posted on 22 May 2014 by Keith Barrington

Some babies after PDA ligation develop a low cardiac output, Patrick McNamara and his colleagues have defined that as being less than 200 mL/kg/min left ventricular output. This cohort study of 30 infants post-ligation, by Afif El-Khuffash and colleagues at … Continue reading →

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