Tag Archives: microbiome

Necrotizing Enterocolitis: manipulating the microbiome, part 2

Posted on 6 May 2016 by Keith Barrington

The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading →

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Necrotizing Enterocolitis: manipulating the microbiome, part 1

Posted on 6 May 2016 by Keith Barrington

Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading →

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Prebiotics, Probiotics and the microbiome

Posted on 2 October 2015 by Keith Barrington

A series of interesting recent articles: Yang J, et al. Application of Laser Capture Microdissection and 16S rRNA Gene Polymerase Chain Reaction in the Analysis of Bacteria Colonizing the Intestinal Tissue of Neonates With Necrotizing Enterocolitis. Pediatr Infect Dis J. … Continue reading →

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Frozen poop sounds much more palatable

Posted on 7 November 2014 by Keith Barrington

Fecal transplants are effective in treatment of persistent clostridium difficile infections. The publication showing that, in the small RCT published in the PNEJM, was remarkable in the pre-screened donors who were ready and available to produce a “donation” on demand. … Continue reading →

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Stop the Antibiotics!

Posted on 21 February 2014 by Keith Barrington

We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading →

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Your mother is the source of your microbiome

Posted on 12 February 2014 by Keith Barrington

An interesting review article from last year (free access) which discusses information from many different species, several non-mammalian, that show that, not too surprisingly, our mothers are the source of our microbiome. They speculate that the bacterial contamination of breast … Continue reading →

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Probiotics : Time for Action

Posted on 10 February 2014 by Keith Barrington

As I have noted before on this blog, our article showing the effects of the introduction of routine probiotics in our NICU has been published on-line. The Journal of Pediatrics decided to accompany it with an editorial by William Tarnow-Mordi … Continue reading →

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Banking on it

Posted on 10 November 2013 by Keith Barrington

I guess this was the next step, after blood banks, and human milk banks, the next big advance is a poop bank. Although we don’t know if autologous stool transplants will be as successful as donor stool to treat C … Continue reading →

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The Microbiome and NecrotiSing Enterocolitis

Posted on 6 October 2013 by Keith Barrington

Fortunately Pubmed speaks both English and American, if you search on Pubmed for necrotizing enterocolitis it also gives you articles about correctly spelt gut diseases in preterm infants as well. As a North American transplant my spelling has become a … Continue reading →

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Bugs in the news

Posted on 11 April 2013 by Keith Barrington

Many thanks to Girish Deshpande for sending me a link to an Australian news item about probiotics and their use in the preterm, a 2 minute video clip for your edification. http://www.abc.net.au/news/2013-04-10/new-hope-for-premature-babies/4619984 The excellent science blogs ‘Phenomena’ have an article … Continue reading →

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