Tag Archives: Hypotension

Return to the Regression to the Mean

Posted on 5 November 2025 by Keith Barrington

After my post on regression to the mean, and its importance in studies of apnoea therapy, I was thinking of other examples. Some which have been most evident to me are those which impact on areas of medicine that I … Continue reading →

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Hypotension and Shock. Optimising treatments

Posted on 27 May 2025 by Keith Barrington

A new single centre RCT of permissive hypotension (PH) compared to “standard treatment” (ST) of very preterm infants 24 to <30 weeks GA, with a mean BP lower than their GA has just appeared (Alderliesten T, et al. Treatment of … Continue reading →

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Early hydrocortisone in shock?

Posted on 21 February 2025 by Keith Barrington

A few years ago, we published our experience with the use of hydrocortisone in newborn infants in septic shock (Altit G, et al. Corticosteroid Therapy in Neonatal Septic Shock-Do We Prevent Death? Am J Perinatol. 2018;35(2):146-51), like many such studies … Continue reading →

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To bolus or not to bolus? Not really a question…

Posted on 19 December 2023 by Keith Barrington

Many preterm babies receive boluses of normal saline, often during the first 24 hours when their blood pressure is lower than desired. I have 3 serious questions about this. The rationale for giving a fluid bolus is that the infant … Continue reading →

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Cardiovascular support in the preterm, how to determine adequate perfusion?

Posted on 17 January 2022 by Keith Barrington

As many of you will know, I have advocated for many years for evaluation and management of very preterm babies based on their tissue perfusion rather than the blood pressure. There is little or no correlation between BP and perfusion, … Continue reading →

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Opioid infusions for ventilated preterm babies

Posted on 13 September 2021 by Keith Barrington

Many practices in neonatology are variable between NICUs, and many vary from year to year; without any good scientific data practices become fashionable or routine or ingrained without necessarily having an evidence base to support them. One such practice is … Continue reading →

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Under Pressure….

Posted on 26 August 2015 by Keith Barrington

Colm O’Donnell once wrote an article with a whole line from a David Bowie song embedded in the article’s title (O’Donnell CPF. Turn and face the strange – ch..ch..ch..changes to neonatal resuscitation guidelines in the past decade. Journal of Paediatrics … Continue reading →

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Treatment of hypotension in the very preterm infant

Posted on 16 January 2014 by Keith Barrington

When hypotension should be treated and with what are important and difficult questions in the care of the very preterm infant. The international HIP collaboration (see the link in the side bar) has been funded to try and find some … Continue reading →

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