Author Archives: Keith Barrington

About Keith Barrington

I am a neonatologist and clinical researcher at Sainte Justine University Health Center in Montréal

More randomized trials of magic in newborn infants

The scientific basis of neonatology is vitally important to me, the enormous advances that we have made have all been founded on basic and clinical science. So I can get quite agitated when I see articles reporting trials of interventions … Continue reading

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Does knowing the genetic abnormality change management? And should it?

Just after I pressed “post” for a recent addition to the blog, I saw this appear. (Callahan KP, et al. Influence of Genetic Information on Neonatologists’ Decisions: A Psychological Experiment. Pediatrics. 2022;149). It illustrates some major problems in how neonatologists … Continue reading

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Long term impacts of antenatal steroids

To return to a concern expressed in a recent blog, there are animal models and some observational data that suggest that antenatal steroids (ANS) could have a negative effect on cerebral development, at least with the doses used currently. Among … Continue reading

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Should every baby have their Genome sequenced?

Annie Janvier, John Lantos and I have just published an article about Next Generation Sequencing (Janvier A, et al. Next generation sequencing in neonatology: what does it mean for the next generation? Hum Genet. 2022), which is a common way … Continue reading

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Creating smoke-free homes for preterm babies

In response to my previous post about preterms smoking I was directed to a recent publication about the issue, Notley C, et al. Development of a Smoke-Free Home Intervention for Families of Babies Admitted to Neonatal Intensive Care. Int J … Continue reading

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Evidence-based neonatology, or science based neonatology?

To many followers of this blog, the title may seem a little strange; is there any difference? Surely science underlies all of our field, and testing treatments in adequately designed trials leads to progressive improvements through the application of evidence-based … Continue reading

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Antenatal steroids prior to late preterm delivery; still many questions, but a major shift in practice.

It can sometimes take years for major advances in medicine, based on clear evidence of improved outcomes, to lead to shifts in practice. One example is the initial demonstration by Liggins and Howie that antenatal steroids (ANS) improved survival of … Continue reading

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Preterm babies, PLEASE don’t smoke!

One of the most addictive and harmful drugs of all is perfectly legal. Tobacco, and the nicotine it contains, are subject to prohibition for adults nowhere in the world, despite millions of deaths, prolonged severe disability, and being probably as … Continue reading

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We need to rethink neonatal hypoglycaemia

A great deal of time and effort is expended to detect and treat low blood sugars in the newborn. Studies to determine risk factors, monitoring schedules, and treatment strategies have taken a great deal of effort, and implementing the recommended … Continue reading

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Steroids to improve pulmonary outcomes in preterm infants.

When we consider using steroids in a preterm infant, ventilator dependent, with evolving lung disease, what outcomes are we most interested in? Survival, surely, is the first outcome that we want to improve, and secondly long-term pulmonary health. The adverse … Continue reading

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