Monthly Archives: May 2018

PAS 2018 No5: the trial with no name… propranolol for early RoP, a proper trial.

Posted on 11 May 2018 by keithbarrington

As far as I can see, this trial has no acronym, which isn’t a big deal, but it also doesn’t show up on trial registry searches, which is a big deal. Trials must be registered before starting them, it ensures … Continue reading →

Posted in Neonatal Research | Tagged , | 8 Comments

PAS 2108 No4: you little SCAMP!

Posted on 10 May 2018 by keithbarrington

In the part of England where I was born and spent the early years of my life, and where my parents are from, the Manchester region, ‘scamp’ was a sort of affectionate term for a young child who had done … Continue reading →

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PAS 2018 No3: Should we TOLERATE the PDA?

Posted on 10 May 2018 by keithbarrington

This was another large multicenter trial, designed to determine if routine attempts to close a moderate to large PDA at the end of the first postnatal week decreases the duration of patency, and the incidence of the combined outcome “need … Continue reading →

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PAS 2018 No2: let’s STOP-BPD

Posted on 10 May 2018 by keithbarrington

The STOP-BPD trial was a multicenter trial from Holland, (registered as NTR2768) over 180 babies were randomized to each arm of this trial, they were <30 weeks or less than 1250 g at birth, and were still ventilated at 2 … Continue reading →

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PAS 2018 No1: SAIL away (and another mention by a science journalist).

Posted on 9 May 2018 by keithbarrington

For some reason there is a small epidemic (n=2, that’s a pico-epidemic) of articles about probiotics and necrotising enterocolitis this year in the mainstream press. I was interviewed, and I am mentioned again, in this article on the NOVA “next” … Continue reading →

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Important outcomes after extreme prematurity: what do parents think?

Posted on 5 May 2018 by keithbarrington

There has been remarkably little study of the response to the question posed in the title: what do parents think is important in the outcomes of the very preterm baby? Physicians have focused on developmental progress, often as measured by … Continue reading →

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Regular universal antibiotics to reduce infant mortality?

Posted on 3 May 2018 by keithbarrington

This (Keenan JD, et al. Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa. The New England journal of medicine. 2018;378(17):1583-92 Open Access) is a new multicenter cluster randomized trial of giving all infants in a community regular azithromycin. If that … Continue reading →

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Too much oxygen is bad for adults too!

Posted on 2 May 2018 by keithbarrington

The systematic review of the neonatal oxygen saturation targeting trials Askie LM, et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane database of systematic reviews (Online). 2017;4:Cd011190. confirmed the increase … Continue reading →

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