Tag Archives: Systematic Reviews

Weekly Updates #3

Posted on 8 August 2012 by Keith Barrington

A few new publications (I know it’s not quite weekly, but I am on vacation!): Nguyen TP, Amon E, Al-Hosni M, Gavard JA, Gross G, Myles TD: “Early” versus “late” 23-week infant outcomes. Am J Obstet Gynecol 2012(0). Not too … Continue reading →

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Improving outcomes of Preterm Infants, early post-discharge intervention programs

Posted on 8 August 2012 by Keith Barrington

The history of early intervention programs is rather mixed. Do they actually help to improve outcomes? The most recent cochrane review was published in 2007 by the amazingly productive Lex Doyle and his colleagues, and was followed by an updated review … Continue reading →

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A toxic placebo

Posted on 8 July 2012 by Keith Barrington

One very frequently used agent in the NICU is metoclopramide, prescribed almost exclusively for gastro-esophgeal reflux, (occasionally in an attempt to improve feeding tolerance). Let us assume for a moment that a baby does have clinical signs which are due to reflux, that … Continue reading →

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Does the way we feed babies affect Necrotizing Enterocolitis?

Posted on 2 July 2012 by Keith Barrington

There is a widespread feeling that the method of introduction and advancement of feeds affects the frequency of necrotizing enterocolitis (known as NEC). Multiple observational studies have been published that seem to support this fear. However when we search for randomized controlled trials comparing feeding practices … Continue reading →

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Perinatal outcomes of IVF twins

Posted on 22 June 2012 by Keith Barrington

Another post about twins and IVF. I’ll back off soon, I promise. A systematic review published just last year notes that the outcomes of twins conceived after IVF is worse than those who are conceived naturally. (Rossi AC, D’Addario V. … Continue reading →

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Long Term outcomes after Therapeutic Hypothermia for HIE

Posted on 13 June 2012 by Keith Barrington

Two new publications from multicenter trials of hypothermia as a treatment for post-asphyxial encephalopathy. The first from the NICHD network, and the whole body cooling study led by Seetha Shankaran. They examined the children and performed IQ testing at 6 to 7 … Continue reading →

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Pain relief and retinopathy screening, part 2.

Posted on 9 May 2012 by Keith Barrington

My good friend Gene Dempsey (a neonatologist and clinical researcher in Cork) reminded me of their trial published in 2010, and suggested that the title of my previous post may be misleading. I guess I really don’t want readers to think that … Continue reading →

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Preventing Prematurity

Posted on 8 May 2012 by Keith Barrington

We’ve known for a while that progesterones can reduce prematurity in certain situations. Intramuscular 17 hydroxy progesterone caproate reduces prematurity in women who have had a previous premature baby. (Meis’s article link below) Now a systematic review of intravaginal progesterone … Continue reading →

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Pain relief during retinopathy screening, nothing works very well.

Posted on 7 May 2012 by Keith Barrington

Mandel R, Ali N, Chen J, Galic IJ, Levesque L: Nitrous oxide analgesia during retinopathy screening: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2012, 97(2):F83-87. http://fn.bmj.com/content/97/2/F83 My colleagues and friends Romain Mandel and Nabeel Ali performed a … Continue reading →

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Probiotics to Prevent NEC: Why aren’t we saving babies yet?

Posted on 5 May 2012 by Keith Barrington

The latest systematic review of Probiotics to Prevent NEC in Preterm infants Wang Q, Dong J, Zhu Y: Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials. J … Continue reading →

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