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Meta
Tag Archives: Sepsis
Sense about Sepsis
Recent guidelines regarding the evaluation and treatment of early onset sepsis, or the baby who has risk factors, have been widely criticized. Especially by me! And by me! The AAP for example recommends antibiotic treatment for all infants born after … Continue reading
Should we all be wearing gloves? Every time we touch a baby?
Two new articles over the summer suggest that the answer to that question may well be yes. The first is the best quality of the studies, an RCT in a single center in the USA. Kaufman DA, Blackman A, Conaway MR, Sinkin … Continue reading
Posted in Neonatal Research
Tagged infection control, Randomized Controlled Trials, Sepsis
2 Comments
Sniffing out lung injury
Apparently exhaled breath analysis can be used to detect a number of pulmonary and systemic diseases. As a medical student I was taught about some of the classical clinical signs of certain diseases (such as diabetic ketoacidosis) which make the … Continue reading
Position statements and overtreatment
A few years ago when I was chair of the Canadian Paediatric Society Fetus and Newborn Committee, we produced a statement about what to do with full term babies with risk factors for sepsis. Our recommendation was, to put it … Continue reading
New Lactoferrin Data
Two new articles addressing effects of lactoferrin. Both used bovine lactoferrin (bLF), one was in humans, the other in piglets. In case you haven’t been following closely, lactoferrin is an iron transport protein that has multiple anti-infective properties, against bacteria, … Continue reading
Posted in Neonatal Research
Tagged Necrotising Enterocolitis, Randomized Controlled Trials, Sepsis
1 Comment
Hero: Not just for infections any more
Sullivan BA, Grice SM, Lake DE, Moorman JR, Fairchild KD. Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. The Journal of pediatrics. 2014. Monitoring for abnormal heart rate characteristics has previously been shown in a … Continue reading
Something else that doesn’t work in sepsis; albumin
Another multi-center RCT in adults with severe sepsis or septic shock with a negative result. This time 1800 adults in 100 ICUs in Italy were randomized. Fluid boluses were either crystalloid or 20% albumin and crystalloid. Blood pressure was somewhat … Continue reading
Zinc supplementation: should we be galvanized into action?
I wasn’t sure how many non native-English speakers would get that joke, and jokes are rarely improved by explaining them, so if you don’t get it, just keep on reading. Terrin G, Berni Canani R, Passariello A, Messina F, Conti … Continue reading
Posted in Neonatal Research
Tagged breast milk, Necrotising Enterocolitis, Randomized Controlled Trials, Sepsis
2 Comments
Septic Shock; 3 negative trials
Three trials back to back in the PNEJM (that’s the prestigious New England Journal of Medicine for any new readers) in adults with septic shock are disappointing: Early Goal Directed Therapy has become a dogma in recent years; it even … Continue reading
Cohort study of Probiotics in our NICU
Our article describing the results of introducing routine probiotic prophylaxis in our NICU has just become available on-line. Janvier A, Malo J, Barrington KJ: Cohort Study of Probiotics in a North American Neonatal Intensive Care Unit. The Journal of pediatrics … Continue reading
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