Tag Archives: Research Design

Pluto, not just a planet anymore.

Posted on 11 September 2013 by Keith Barrington

Or should that be, not even a planet… One other thing I wanted to mention about the PLUTO trial is the entry criterion. The main entry criterion was the presence of clear lower urinary tract obstruction in a male fetus, … Continue reading →

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Who was Bayes, and what did he know about medical research?

Posted on 11 September 2013 by Keith Barrington

I don’t have much detail to answer the first question: he was an 18th century English mathematician who wrote something about probability, that was published after he died. That publication described something called Bayes’ theorem which is a way of … Continue reading →

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We didn’t find what we wanted to find, so we thought we’d re-analyze the data until we found it.

Posted on 26 August 2013 by Keith Barrington

…oh and by the way, we are the manufacturers making the product in question, so we had objective scientific reasons for doing this, no conflict of interest whatever. The commercial sponsors of a negative trial decided that they didn’t like … Continue reading →

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