Tag Archives: Research Design

Leave my renal nerves alone, please.

Posted on 10 March 2014 by Keith Barrington

Not having looked after an adult for many years (although I did do a year of postgraduate training in adult internal medicine before switching to paediatrics; I thought I should practice on the old ones before subjecting children to my … Continue reading →

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If massage is so good, how come the research is so bad?

Posted on 5 February 2014 by Keith Barrington

I think its likely that massage therapy for the preterm infant has some benefits, unfortunately much of the research is under-powered, badly designed, inappropriately analyzed and overinterpreted. A case in point is a new study in Early Human Development, which … Continue reading →

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Improving research

Posted on 14 January 2014 by Keith Barrington

A series of articles from a group of the great and the good in clinical research methodology and design. (Including Iain Chalmers and John Ioannidis). They all seem to be open access, and make some very important points and good … Continue reading →

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Personalized Medicine in the NICU

Posted on 20 November 2013 by Keith Barrington

An article I wrote, with that title, as an open peer commentary in the American Journal of Bioethics has just appeared on-line. The first 50 people to click on the link at the bottom of this post below can get a free full … Continue reading →

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Registry Trials

Posted on 30 October 2013 by Keith Barrington

The latest PNEJM reports a large trial in adults (over 7000 patients randomized) in a very tasty trial, known as TASTE (Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia). The trial was among patients who were undergoing coronary angiography and … Continue reading →

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Informed consent in the NICU

Posted on 26 September 2013 by Keith Barrington

I have watched most of the presentations at the OHRP meeting, so you don’t have to. Many of the critics of SUPPORT make the same mistaken assumption, that usual care in the NICU is to individualize oxygen saturation targets, I … Continue reading →

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C’est inSUPPORTable!

Posted on 19 September 2013 by Keith Barrington

A new publication about SUPPORT? Haven’t we heard enough? Well no, this is fascinating, although not entirely unexpected if you think about it. One of the 2 comparisons of the SUPPORT trial involved randomization to be either immediately intubated to receive surfactant, … Continue reading →

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What are the responsibilities of clinical researchers?

Posted on 18 September 2013 by Keith Barrington

One of the presentations at the OHRP hearings of the HHS was by George Annas, a JD who has an MPH (for those outside of north america that means he is a lawyer, but with a masters in public health). … Continue reading →

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Pluto, not just a planet anymore.

Posted on 11 September 2013 by Keith Barrington

Or should that be, not even a planet… One other thing I wanted to mention about the PLUTO trial is the entry criterion. The main entry criterion was the presence of clear lower urinary tract obstruction in a male fetus, … Continue reading →

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Who was Bayes, and what did he know about medical research?

Posted on 11 September 2013 by Keith Barrington

I don’t have much detail to answer the first question: he was an 18th century English mathematician who wrote something about probability, that was published after he died. That publication described something called Bayes’ theorem which is a way of … Continue reading →

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