Tag Archives: Randomized Controlled Trials

Mind your ABC’s : Artificial respiration Before Cord clamping?

Posted on 23 May 2024 by Keith Barrington

Delayed cord clamping has, rightly, become the default whenever a newborn infant is born, benefits in term, late preterm, and very preterm infants have been shown. Current guidelines suggest that if the infant “needs resuscitation” then immediate clamping and assisted … Continue reading →

Posted in Neonatal Research | Tagged , , , , | 6 Comments

The role of Ureaplasma in Chronic Lung Disease of Prematurity

Posted on 20 May 2024 by Keith Barrington

There have long been questions about the possible role of ureaplasma in the pathogenesis of BPD. Studies have shown a statistical association between maternal colonization and BPD, between placentas showing evidence of the germ, and between neonatal endotracheal colonization and … Continue reading →

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Intravenous Nutrition of the sick term and late preterm infants : part 2.

Posted on 17 May 2024 by Keith Barrington

The other trial is a much larger multicentre trial with clinical outcomes. (Alexander T, et al. Nutritional Support for Moderate-to-Late-Preterm Infants – A Randomized Trial. N Engl J Med. 2024;390(16):1493-504), the gestational ages only overlapped by 1 week with the … Continue reading →

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Intravenous Nutrition of sick term and late preterm infants : part 1.

Posted on 16 May 2024 by Keith Barrington

There are 2 new trials addressing different aspects of the questions surrounding what to do about TPN for this group of babies. My readers may remember my post about the PEPaNIC trial, which showed that there were disadvantages of early … Continue reading →

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Nasal intubation improves feeding outcomes

Posted on 15 May 2024 by Keith Barrington

The title of the post sneakily did not mention that I am referring to a study in a specific subgroup of babies, the paper is a report of an RCT in newborn infants who had heart surgery. Yildirim MI, et … Continue reading →

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Vitamin A for prevention of lung disease in the preterm

Posted on 13 May 2024 by Keith Barrington

Previous studies have shown that vitamin A supplementation can reduce the frequency of BPD, but the practice has not become widespread. In part, I think, it is because repeated intramuscular injections of vitamin A are the route that has been … Continue reading →

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PAS report 2024: Clinical Trials part 2

Posted on 9 May 2024 by Keith Barrington

The NeoGluCO trial This trial was a modestly sized RCT of low dose diazoxide for treatment of persistent or severe hypoglycaemia in newborn infants of at least 35 weeks gestation. I say “modestly sized” as a descriptor, not a criticism, … Continue reading →

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PAS report 2024: Clinical Trials part 1.

Posted on 9 May 2024 by Keith Barrington

As usual the PAS meeting was packed with neonatology. The App was even worse than last year, crashing frequently on many peoples’ phones. It was completely useless for the posters, as they were listed by number, and the different sessions … Continue reading →

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When you can see what you are doing, you can see what you have done: Video-Laryngoscopy in the newborn

Posted on 8 May 2024 by Keith Barrington

I have been increasingly using video laryngoscopy in my practice, both when I myself perform the intubation, and when I am supervising a resident or other trainee. I usually ask them to use a VL when it is a nurse … Continue reading →

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How should we pasteurize donor breast milk?

Posted on 23 April 2024 by Keith Barrington

The standard method of pasteurization of donor breast milk, and I believe the only method approved by HMBANA (the human milk banking association of north america), is similar to what Louis Pasteur himself came up with a couple of centuries … Continue reading →

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