Tag Archives: Randomized Controlled Trials

Fluid Restricting Babies

Posted on 29 May 2012 by Keith Barrington

A study published online first in the Journal of Pediatrics questions a common practice, the practice of fluid restricting babies who have a patent ductus arteriosus. De Buyst J, Rakza T, Pennaforte T, Johansson AB, Storme L: Hemodynamic Effects of … Continue reading →

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Septic Shock

Posted on 25 May 2012 by Keith Barrington

This study is not neonatal at all, not even pediatric, but I think it is really important. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, et al. Drotrecogin Alfa (Activated) in Adults with Septic Shock. N … Continue reading →

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Weaning from CPAP in preterm babies

Posted on 23 May 2012 by Keith Barrington

There have been very few studies of how to wean babies from CPAP, even though it is something we do all the time. A recent tendency, which seems to have arisen without any supportive data, and which never made much sense … Continue reading →

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Nutrition of very preterm babies

Posted on 11 May 2012 by Keith Barrington

There is a ‘growing’ feeling that we don’t give enough protein to our preterm infants, especially during the enteral phases of nutrition. Fortified maternal breast milk use is associated with lower overall rates of weight gain, despite all its benefits. … Continue reading →

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Pain relief for intramuscular injections

Posted on 10 May 2012 by Keith Barrington

Sometimes we can’t avoid giving an IM injection, even though they are painful. Some vaccines should be given IM, and the routine needle in the thigh of every baby for vitamin K is a rite of passage, that has become standard everywhere. … Continue reading →

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Pain relief and retinopathy screening, part 2.

Posted on 9 May 2012 by Keith Barrington

My good friend Gene Dempsey (a neonatologist and clinical researcher in Cork) reminded me of their trial published in 2010, and suggested that the title of my previous post may be misleading. I guess I really don’t want readers to think that … Continue reading →

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Preventing Prematurity

Posted on 8 May 2012 by Keith Barrington

We’ve known for a while that progesterones can reduce prematurity in certain situations. Intramuscular 17 hydroxy progesterone caproate reduces prematurity in women who have had a previous premature baby. (Meis’s article link below) Now a systematic review of intravaginal progesterone … Continue reading →

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Pain relief during retinopathy screening, nothing works very well.

Posted on 7 May 2012 by Keith Barrington

Mandel R, Ali N, Chen J, Galic IJ, Levesque L: Nitrous oxide analgesia during retinopathy screening: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2012, 97(2):F83-87. http://fn.bmj.com/content/97/2/F83 My colleagues and friends Romain Mandel and Nabeel Ali performed a … Continue reading →

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Can we study Hypotension in Extremely Preterm Infants?

Posted on 5 May 2012 by Keith Barrington

Dr Beau Batton and colleagues from the NICHD network have just published a paper detailing their attempt, and failure, to design a trial of early hypotension treatment. The design looks fine on paper, but when they tried to do the trial there … Continue reading →

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