Tag Archives: Randomized Controlled Trials

Videolaryngoscopy to teach intubation

Posted on 10 March 2016 by Keith Barrington

Two recent randomized trials, one from our group, and another one from Melbourne have evaluate the role of the videolaryngoscope (VL) in teaching trainees in neonatology to perform endotracheal intubations. The two trials are structured differently and tell us different … Continue reading →

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Steroids directly in the lungs? Version 2

Posted on 24 February 2016 by Keith Barrington

A couple of weeks ago I discussed a new multicenter RCT which examined the effects of multiple repeated doses of steroids, given by inhalation starting on the first day of life, and continuing, at least until the infants reached 14 … Continue reading →

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Still more doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

I won’t make a point-by-point response to Reese’s comments, mostly because I agree with most of them! Oxygen is toxic. Minimizing oxygen toxicity is a vitally important issue. Alarm fatigue is a major problem. In our NICU we performed an … Continue reading →

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More Doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

As I just mentioned I received another thoughtful comment from Reese Clark, which I reproduce in its entirety below: “After re-reading my post and at the risk of being a bit redundant with what Dr Barrington has already carefully presented … Continue reading →

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Doubts about BOOSTING saturations?

Posted on 22 February 2016 by Keith Barrington

I received a very thoughtful comment from Reese Clark, who many of you will know as a leader in neonatology whose many years of experience and important scientific contributions to neonatology make him someone worth listening to. He has doubts … Continue reading →

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BOOST-II long term outcomes

Posted on 16 February 2016 by Keith Barrington

The long-running epic of the oxygen saturation targeting trials is nearing completion. This publication of the joint results of the Australia and UK trials now includes the primary outcome for the trials, the combined rate of death or “disability”. Australia … Continue reading →

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Antenatal Steroids at 36 weeks?

Posted on 11 February 2016 by Keith Barrington

Most of the studies of antenatal steroids for lung maturation included mothers at less than 34 weeks. Most babies at 34 to 36 weeks do fine, although there is a growing realization of their increased long term risks. Even the … Continue reading →

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Preventing and Treating Sepsis in Preterm Babies

Posted on 10 February 2016 by Keith Barrington

These two studies are both issues that I am involved with, Theresa Ochoa’s study I was aware of, and was waiting for the full publication, the other, from Egypt, I didn’t know about but should have done, but it confirms … Continue reading →

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Enhanced Nutrition

Posted on 9 February 2016 by Keith Barrington

Strømmen K, et al. Enhanced Nutrient Supply to Very Low Birth Weight Infants is Associated with Improved White Matter Maturation and Head Growth. Neonatology. 2015;107(1):68-75. This is a report of a secondary outcome of a small RCT, there were only … Continue reading →

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The death knell for Xenon?

Posted on 4 February 2016 by Keith Barrington

Azzopardi D, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2016;15(2):145-53.  Babies who undergo therapeutic hypothermia for perinatal encephalopathy … Continue reading →

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