Tag Archives: Randomized Controlled Trials

More Doubts about BOOSTing saturations?

Posted on 22 February 2016 by Keith Barrington

As I just mentioned I received another thoughtful comment from Reese Clark, which I reproduce in its entirety below: “After re-reading my post and at the risk of being a bit redundant with what Dr Barrington has already carefully presented … Continue reading →

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Doubts about BOOSTING saturations?

Posted on 22 February 2016 by Keith Barrington

I received a very thoughtful comment from Reese Clark, who many of you will know as a leader in neonatology whose many years of experience and important scientific contributions to neonatology make him someone worth listening to. He has doubts … Continue reading →

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BOOST-II long term outcomes

Posted on 16 February 2016 by Keith Barrington

The long-running epic of the oxygen saturation targeting trials is nearing completion. This publication of the joint results of the Australia and UK trials now includes the primary outcome for the trials, the combined rate of death or “disability”. Australia … Continue reading →

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Antenatal Steroids at 36 weeks?

Posted on 11 February 2016 by Keith Barrington

Most of the studies of antenatal steroids for lung maturation included mothers at less than 34 weeks. Most babies at 34 to 36 weeks do fine, although there is a growing realization of their increased long term risks. Even the … Continue reading →

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Preventing and Treating Sepsis in Preterm Babies

Posted on 10 February 2016 by Keith Barrington

These two studies are both issues that I am involved with, Theresa Ochoa’s study I was aware of, and was waiting for the full publication, the other, from Egypt, I didn’t know about but should have done, but it confirms … Continue reading →

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Enhanced Nutrition

Posted on 9 February 2016 by Keith Barrington

Strømmen K, et al. Enhanced Nutrient Supply to Very Low Birth Weight Infants is Associated with Improved White Matter Maturation and Head Growth. Neonatology. 2015;107(1):68-75. This is a report of a secondary outcome of a small RCT, there were only … Continue reading →

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The death knell for Xenon?

Posted on 4 February 2016 by Keith Barrington

Azzopardi D, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2016;15(2):145-53.  Babies who undergo therapeutic hypothermia for perinatal encephalopathy … Continue reading →

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Surfactant without intubation, where are we?

Posted on 4 February 2016 by Keith Barrington

A recent trial from Germany tried to answer the question of whether giving surfactant through a thin catheter while the baby was on CPAP would reduce “death or BPD” compared to intubation for surfactant. Kribs A, et al. Nonintubated Surfactant Application … Continue reading →

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When to deliver after Preterm Ruptured Membranes

Posted on 2 February 2016 by Keith Barrington

I have often wondered why my obstetrical colleagues would often induce labour once a woman with ruptured membranes reached 34 weeks. I wasn’t aware of any data to support doing this, or, on the other hand, any good data to … Continue reading →

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The best outcome variable for very preterm newborns?

Posted on 27 November 2015 by Keith Barrington

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading →

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