Tag Archives: Necrotising Enterocolitis

Oxygen, transfusions, and NEC

Posted on 31 March 2014 by Keith Barrington

What causes NEC! The answer is ‘who knows?’, or perhaps a better one would be ‘its complicated…’ You probably need an immature gut, gut mucosal injury, inflammation and cytokine release, and an abnormal microbiome, all of which probably interact in … Continue reading →

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Transfusion Associated Necrotizing EnteroColitis?

Posted on 29 March 2014 by Keith Barrington

I’m still not absolutely sure about TANEC, as it now seems to be called. It is certainly possible that transfusions could trigger gut injury in very preterm babies, but how to prove it? Even if the temporal association was absolutely … Continue reading →

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Stop the Antibiotics!

Posted on 21 February 2014 by Keith Barrington

We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading →

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Yet more probiotic stuff

Posted on 14 February 2014 by Keith Barrington

Here is the other study of saccharomyces that I mentioned previously on this blog (Demirel G, Erdeve O, Celik IH, Dilmen U: Saccharomyces boulardii for prevention of necrotizing enterocolitis in preterm infants: A randomized, controlled study. Acta Paediatrica 2013) recently … Continue reading →

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Probiotics : Time for Action

Posted on 10 February 2014 by Keith Barrington

As I have noted before on this blog, our article showing the effects of the introduction of routine probiotics in our NICU has been published on-line. The Journal of Pediatrics decided to accompany it with an editorial by William Tarnow-Mordi … Continue reading →

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Cohort study of Probiotics in our NICU

Posted on 13 January 2014 by Keith Barrington

Our article describing the results of introducing routine probiotic prophylaxis in our NICU has just become available on-line. Janvier A, Malo J, Barrington KJ: Cohort Study of Probiotics in a North American Neonatal Intensive Care Unit. The Journal of pediatrics … Continue reading →

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Probiotics work, they really, really, work! (And they are safe)

Posted on 22 November 2013 by Keith Barrington

The Proprems study that I have referred to a couple of times before has now been published. This was a multicenter RCT of a probiotic preparation in 1100 very preterm infants less than 1500 grams and less than 32 weeks. … Continue reading →

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Feeding during PDA treatment

Posted on 15 October 2013 by Keith Barrington

Ron Clyman and a multicenter group have just published this DAFFII trial. Which is a rather tortuous light-hearted acronym for Ductus Arteriosus Feed or Fast with Indomethcain or Ibuprofen.   (Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka … Continue reading →

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Therapeutic Hypothermia: not a panacea

Posted on 11 October 2013 by Keith Barrington

If hypothermia protects the brain, maybe we should use it for anyone who is at risk of brain injury during acute illness? Fortunately other potential uses of hypothermia are being investigated, such as this:  Mourvillier B, Tubach F, van de Beek D, … Continue reading →

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The Microbiome and NecrotiSing Enterocolitis

Posted on 6 October 2013 by Keith Barrington

Fortunately Pubmed speaks both English and American, if you search on Pubmed for necrotizing enterocolitis it also gives you articles about correctly spelt gut diseases in preterm infants as well. As a North American transplant my spelling has become a … Continue reading →

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