Tag Archives: long term outcomes

Steroids and BPD, what do we really know?

Posted on 26 March 2026 by Keith Barrington

My first foray into systematic review and meta-analysis was about 25 years ago with this article Barrington KJ. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr. 2001;1:1. As you can … Continue reading →

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Neonatal Research Shorts : February 2026

Posted on 17 March 2026 by Keith Barrington

Dereymaeker A, et al. Neonatal sleep physiology and early executive functioning in preterm children. Pediatr Res. 2026. In this observational study, the authors recorded sleep architecture overnight shortly prior to discharge of 76 preterm infants, averaging 30 weeks GA. The … Continue reading →

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Managing Post-Haemorrhagic Hydrocephalus

Posted on 2 March 2026 by Keith Barrington

PHH, as I will call it, is an extremely important determinant of outcomes in a small subgroup of preterm infants. Infants with severe IVH who don’t develop PHH have outcomes that are little affected. As our group reviewed, even grade … Continue reading →

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Should we ever close the PDA?

Posted on 10 December 2025 by Keith Barrington

The latest large multicentre RCT has just been published. Laughon MM, et al. Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants. JAMA. 2025. In this trial, infants of 22 to 28 weeks GA were randomized at between … Continue reading →

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Hope for HIE

Posted on 20 November 2025 by Keith Barrington

I was struck this morning by a new article in Pediatric Research a “Family Perspectives” written by the founder of the organisation that has the same name as the title of this post, “Hope for HIE“, Betsy Pilon (Pilon B. … Continue reading →

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Longer term outcomes after cooling

Posted on 13 November 2025 by Keith Barrington

One of the numerous major advances in neonatology during my career has been the introduction of therapeutic hypothermia for infants with Hypoxic Ischemic Encephalopathy (HIE). Mortality is decreased, by about 25%, and long term morbidity among survivors is also decreased, … Continue reading →

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Neonatal Research Shorts : November 2025

Posted on 10 November 2025 by Keith Barrington

Ybarra M, et al. Low-Grade Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Concomitant Preterm Brain Injuries: Neurodevelopmental Outcomes at 3 Years of Age. J Pediatr. 2025:114713. Previous studies of the long term outcome of infants with germinal matrix or low grade IVH … Continue reading →

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Neonatal Research Shorts : October 2025

Posted on 2 October 2025 by Keith Barrington

Afifi J, et al. Atropine Versus Placebo for Neonatal Nonemergent Intubation: A Randomized Clinical Trial. J Pediatr. 2025;286:114719 I had thought this was a settled issue, Neil Finer showed many years ago that atropine alone decreased bradycardias during intubation. But … Continue reading →

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Predicting neurological and developmental outcomes. Why? How?

Posted on 29 September 2025 by Keith Barrington

There are a huge number of publications correlating medium term outcomes (by which I mean outcomes around 1 to 2 years of age) with findings in the neonatal period. Most have concerned various approaches to brain imaging, although other studies … Continue reading →

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Caffeine is good for the preterm brain; might more caffeine be even better?

Posted on 24 September 2025 by Keith Barrington

One of the pivotal RCTs in neonatology was the CAP study (Schmidt B, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357(19):1893–902). We performed that study because there was no data on the … Continue reading →

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