Tag Archives: Hypothermia

Therapeutic Hypothermia at 35 weeks

Posted on 11 April 2025 by Keith Barrington

In response to a couple of thoughtful comments to my previous post, I thought I would try to address the specific issue of the infant of 35 weeks. (Faix RG, et al. Whole-Body Hypothermia for Neonatal Encephalopathy in Preterm Infants … Continue reading →

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Therapeutic Hypothermia in the Late Preterm Infant

Posted on 9 April 2025 by Keith Barrington

Current guidelines support the use of therapeutic hypothermia for term infants with hypoxic ischaemic encephalopathy. Both the Canadian and the US guidelines include infants born at 35 weeks gestation. However, the data supporting efficacy for those late preterm infants, is … Continue reading →

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Neonatal Research Shorts : April 2025

Posted on 7 April 2025 by Keith Barrington

I used to do a series of shorter posts called “weekly updates” but I ran out of steam and have concentrated on longer posts in recent years. The last couple of weeks, with clinical service, I have had less time … Continue reading →

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PAS 2023, some selected stuff

Posted on 8 May 2023 by Keith Barrington

Hernia repair timing One trial which will should have an impact on the care of newborn infants is the trial of early versus late hernia repair. 40 neonatal centres in the USA randomized 320 preterm infants to inguinal hernia repair … Continue reading →

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Erythropoietin does not protect the brain, what next?

Posted on 27 July 2022 by Keith Barrington

The latest trial to fail to find a benefit of erythropoietin (Epo) for neonatal brain protection has just been published (Wu YW, et al. Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns. N Engl J Med. 2022;387(2):148-59). The HEAL trial, … Continue reading →

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What to do with mild encephalopathy?

Posted on 13 November 2017 by Keith Barrington

Therapeutic hypothermia improves the chances of babies with moderate or severe hypothermia of surviving without serious disability; referrals for evaluation for therapeutic hypothermia have exploded in our center, and many others, now that this advance is widely acknowledged. Many of … Continue reading →

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Erythropoietin for Asphyxia

Posted on 9 May 2016 by Keith Barrington

A preliminary RCT in babies undergoing therapeutic hypothermia (Wu YW, et al. High-dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016). They randomized 50 babies with HIE who were being cooled to 1000 units/kg on days 1,2,3,5, … Continue reading →

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Time is Brain

Posted on 17 October 2013 by Keith Barrington

That phrase, which has been used to denote the urgency of early stroke treatment in adults, has been purloined by Marianne Thoresen and her colleagues for their article about the importance of timely hypothermia treatment, and now by me for … Continue reading →

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Therapeutic Hypothermia: not a panacea

Posted on 11 October 2013 by Keith Barrington

If hypothermia protects the brain, maybe we should use it for anyone who is at risk of brain injury during acute illness? Fortunately other potential uses of hypothermia are being investigated, such as this:  Mourvillier B, Tubach F, van de Beek D, … Continue reading →

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