Tag Archives: CPAP

Face masks for resuscitation?

Posted on 12 November 2025 by Keith Barrington

Blank DA, et al. Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial. Lancet Child Adolesc Health. 2025;9(10):715–23. An excellent acronym for this trial. Hopefully it … Continue reading →

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Non-invasive high-frequency oscillation; worth the hassle?

Posted on 29 October 2025 by Keith Barrington

Non-invasive HFOV can be delivered by a variety of different equipment and interfaces. The high flows and upper airway turbulence probably have an impact on gas exchange; It appears that the effective dead space of the oro-nasopharynx is washed out … Continue reading →

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Prolonging CPAP in the preterm to improve pulmonary outcomes

Posted on 8 April 2025 by Keith Barrington

I wrote about this trial after last year’s PAS meeting, mentioning that it looked like a potential significant improvement in respiratory care of the preterm The full publication confirms that is a real possibility. McEvoy CT, et al. Extended Continuous … Continue reading →

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Delivering better CPAP in the delivery room, can we avoid intubation in the most immature babies?

Posted on 7 October 2021 by Keith Barrington

Randomized trials have shown that trying to prevent intubation in the DR leads to less severe lung injury. The Cochrane review of prophylactic CPAP compared to immediate intubation included 3 trials (SUPPORT, COIN and DR Management study), that review found … Continue reading →

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High-flow in non-tertiary neonatal units: Hunting for answers. #EBNEO

Posted on 27 May 2019 by Keith Barrington

I think Brett Manley is going for the record as the person with the highest proportion of his publications in the FPNEJM, he now has 3, with 2 of them as first author. This is the HUNTER trial where babies … Continue reading →

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Under Pressure…

Posted on 7 November 2018 by Keith Barrington

This post “under pressure” isn’t about the classic collaboration between David Bowie and Queen at Live Aid, rather it is about how to wean CPAP. Should we trial preterm babies off for a period every day, or either progressively reduce … Continue reading →

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PAS 2018 No7: Protecting tiny noses

Posted on 14 May 2018 by Keith Barrington

#NeoEBM My blog posts are automatically tweeted. A group of twitterers got together at PAS and suggested that this hashtag should become a marker of neonatal Evidence Based Medicine posts. Great initiative! Now I have to find out how to … Continue reading →

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PAS 2018 No6: Brett, the HUNTER

Posted on 12 May 2018 by Keith Barrington

Brett Manley from Melbourne is now the person in the world with the greatest trial experience in the use of high flow nasal cannulae in the newborn. He has been the HIPSTER, and is now the HUNTER, I can’t find … Continue reading →

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Cannulae for CPAP and nasal ventilation

Posted on 17 June 2015 by Keith Barrington

Mukerji A, Belik J. Neonatal nasal intermittent positive pressure ventilation efficacy and lung pressure transmission. J Perinatol. 2015. This is a lung model study, in which the authors compared the pressure transmission and CO2 elimination effects of nasal IPPV with … Continue reading →

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What’s new with Caffeine?

Posted on 27 April 2015 by Keith Barrington

Lodha A, et al. Association of Early Caffeine Administration and Neonatal Outcomes in Very Preterm Neonates. JAMA Pediatr. 2014. First, a study of which I was a co-author; we examined from the CNN whether infants that received caffeine starting in … Continue reading →

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