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Meta
Tag Archives: BPD
Inhaled steroids to prevent BPD, another trial.
This time from Japan, Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a randomised controlled trial. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2016. 211 babies with a birth weight less than 1000 … Continue reading
Late surfactant supplementation
After the initial phase of surfactant deficiency of the very preterm infant, inhibition and destruction of surfactant are common, the inflammation of the oxygen exposed preterm lung is probably important in the pathophysiology of bronchopulmonary dysplasia, and the adverse effects … Continue reading
Posted in Neonatal Research
Tagged BPD, Randomized Controlled Trials, surfactant treatment
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Early low dose systemic hydrocortisone to prevent death or chronic lung disease? Hold on a bit.
An important high quality trial has just been published, it has taken me a bit longer than usual to process the new info. Among other reasons a nice review was posted on the “other neonatal blog“, but I wanted to … Continue reading
Posted in Neonatal Research
Tagged BPD, long term outcomes, mortality, Randomized Controlled Trials, steroids
2 Comments
Steroids directly in the lungs? Version 2
A couple of weeks ago I discussed a new multicenter RCT which examined the effects of multiple repeated doses of steroids, given by inhalation starting on the first day of life, and continuing, at least until the infants reached 14 … Continue reading
Posted in Neonatal Research
Tagged BPD, Randomized Controlled Trials, steroids, surfactant treatment
1 Comment
Surfactant without intubation, where are we?
A recent trial from Germany tried to answer the question of whether giving surfactant through a thin catheter while the baby was on CPAP would reduce “death or BPD” compared to intubation for surfactant. Kribs A, et al. Nonintubated Surfactant Application … Continue reading
Posted in Neonatal Research
Tagged BPD, endotracheal intubation, Randomized Controlled Trials, surfactant treatment
1 Comment
The last nail in the coffin of permissive hypercapnia?
Thome UH, et al. Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. Lancet Respir Med. 2015;3(7):534-43. This German multi-center trial randomized infants 400 to 1000 g birth weight to 2 different CO2 target ranges. The … Continue reading
Late Surfactant may not be effective, probably.
A large multi-center trial (n=511) led by Roberta Ballard has just been published. (Ballard RA, et al. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr 2015.) In this trial infants had similar … Continue reading
Posted in Neonatal Research
Tagged BPD, mortality, Randomized Controlled Trials, Research Design, surfactant treatment
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Early steroids to prevent Chronic Lung Disease; give them directly into the lungs?
Bassler D, et al. Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia. New England Journal of Medicine. 2015;373(16):1497-506. One of those ongoing trials that we have been awaiting the results of has just been published. The NEUROSIS trial was a … Continue reading
NICUs are working better: still room for improvement.
As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading
Posted in Neonatal Research
Tagged BPD, mortality, Necrotising Enterocolitis, Retinopathy of Prematurity, Sepsis
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Under Pressure….
Colm O’Donnell once wrote an article with a whole line from a David Bowie song embedded in the article’s title (O’Donnell CPF. Turn and face the strange – ch..ch..ch..changes to neonatal resuscitation guidelines in the past decade. Journal of Paediatrics … Continue reading
Posted in Neonatal Research
Tagged BPD, Hemodynamics, Hypotension, intracranial hemorrhage, mortality
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