Tag Archives: BPD

Inhaled steroids for BPD?

Posted on 12 December 2016 by Keith Barrington

In a recent post I promoted a new Barrington rule for meta-analysis (it probably already existed somewhere but I am claiming priority anyway, it’s a “post-truth” kind of thing). The rule was that in a systematic review you shouldn’t pool … Continue reading →

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Neonatal Updates: Recent Nutritional Publications part 1.

Posted on 16 August 2016 by Keith Barrington

As there is no way I can catch up after the break, I will post a few ‘neonatal Updates’ to point my readers to things I found interesting over the last couple of months, this first group is all about … Continue reading →

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Causes and Consequences of Bronchopulmonary Dysplasia

Posted on 21 June 2016 by Keith Barrington

Sullivan K, et al. The Association between Positive Tracheal Aspirate Cultures and Adverse Pulmonary Outcomes in Preterm Infants with Severe Bronchopulmonary Dysplasia. American journal of perinatology. 2016(EFirst).  This is an interesting study, with many limitations. 121 intubated VLBW preterm infants … Continue reading →

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Caffeine protects the lungs

Posted on 7 June 2016 by Keith Barrington

From the CAP trial we know that caffeine administration leads to less bronchopulmonary dysplasia. The question is how? The mechanism could help to design other studies, or help in a decision about clinical use where the question hasn’t been directly … Continue reading →

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How to define BPD

Posted on 13 May 2016 by Keith Barrington

An article published at the end of 2015, (I only just got the full-text) compared 3 diagnostic criteria for defining BPD. The original 36 week threshold by Andy Shennan, the NIH workshop definition, and the ‘physiologic’ definition requiring a room-air … Continue reading →

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CMV transmission by breast milk in the very preterm, how important is it?

Posted on 11 May 2016 by Keith Barrington

Over the past couple of years there have been quite a few articles addressing this issue, so I guess it must be important. The results of all these studies are not consistent, however, Kelly MS, et al. Postnatal Cytomegalovirus Infection … Continue reading →

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Which Surfactant is best?

Posted on 5 May 2016 by Keith Barrington

Singh N, et al. Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants. Cochrane database of systematic reviews (Online). 2015;12:CD010249. This is the sort of systematic review that I find really helpful. Some … Continue reading →

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Follow up of the PREMILOC post

Posted on 12 April 2016 by Keith Barrington

Further to my post about the PREMILOC trial of routine hydrocortisone supplementation in extremely preterm infants, I received an email response from Olivier Baud, who was generally in agreement with my comments, but doubts the validity of adding the data … Continue reading →

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Inhaled steroids to prevent BPD, another trial.

Posted on 12 April 2016 by Keith Barrington

This time from Japan, Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a randomised controlled trial. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2016. 211 babies with a birth weight less than 1000 … Continue reading →

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Late surfactant supplementation

Posted on 8 April 2016 by Keith Barrington

After the initial phase of surfactant deficiency of the very preterm infant, inhibition and destruction of surfactant are common, the inflammation of the oxygen exposed preterm lung is probably important in the pathophysiology of bronchopulmonary dysplasia, and the adverse effects … Continue reading →

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