Category Archives: Neonatal Research

Neonatal Research Shorts : March 2026

Posted on 27 March 2026 by Keith Barrington

Pineda R, et al. Language and sound exposure across neonatal intensive care hospitalization and relationships with early outcome. J Perinatol 2026. In this short term outcome study, 64 very preterm infants <29 weeks GA were evaluated at near-term age with … Continue reading →

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Steroids and BPD, what do we really know?

Posted on 26 March 2026 by Keith Barrington

My first foray into systematic review and meta-analysis was about 25 years ago with this article Barrington KJ. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr. 2001;1:1. As you can … Continue reading →

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Registration of clinical trials.

Posted on 20 March 2026 by Keith Barrington

Since 2005 the International Committee of Medical Journal Editors has required that a condition of publication of a prospective controlled trial is that it should be registered in an accessible database prior to starting the trial. It is understandable that … Continue reading →

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Neonatal Acute Respiratory Distress Syndrome, what is it and how should we treat it?

Posted on 20 March 2026 by Keith Barrington

ARDS is a fairly common problem in the adult and the paediatric ICU; following trauma, or systemic sepsis, or other extrapulmonary insults, usually inflammatory in nature, or as a complication of direct pulmonary insults, such as pneumonia or aspiration of … Continue reading →

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Neonatal Research Shorts : February 2026

Posted on 17 March 2026 by Keith Barrington

Dereymaeker A, et al. Neonatal sleep physiology and early executive functioning in preterm children. Pediatr Res. 2026. In this observational study, the authors recorded sleep architecture overnight shortly prior to discharge of 76 preterm infants, averaging 30 weeks GA. The … Continue reading →

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Optimizing ventilation in established BPD

Posted on 13 March 2026 by Keith Barrington

Babies with established BPD (I won’t worry about the exact diagnostic criteria here, but very preterm infants who are still ventilated as they approach term are the group I am talking about) have somewhat reduced compliance, increased airways resistance, leading … Continue reading →

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Managing Post-Haemorrhagic Hydrocephalus

Posted on 2 March 2026 by Keith Barrington

PHH, as I will call it, is an extremely important determinant of outcomes in a small subgroup of preterm infants. Infants with severe IVH who don’t develop PHH have outcomes that are little affected. As our group reviewed, even grade … Continue reading →

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Give your opinion: what should we call the most immature babies?

Posted on 27 February 2026 by Keith Barrington

There is an upcoming workshop, sponsored by the AAP, and other groups, that is investigating what shared language should be used for the babies of less than 25 weeks gestation. At present there are not as many responses as they … Continue reading →

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Automated oxygen control; is it worth it?

Posted on 18 February 2026 by Keith Barrington

The history of automated controls of inspired oxygen goes back many decades, to before the invention of pulse oximetry. The first studies I remember used transcutaneous PO2 as the target variable, which had major limitations, as well as the advantage … Continue reading →

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Prophylactic acetaminophen in the preterm

Posted on 17 February 2026 by Keith Barrington

In a newly published trial (Roze JC, et al. Prophylactic Treatment of Patent Ductus Arteriosus With Acetaminophen: A Randomized Clinical Trial. JAMA Pediatr. 2026) nearly 800 infants of 23 to <29 weeks GA were randomized within 12 hours of birth. … Continue reading →

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