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Author Archives: Keith Barrington
Necrotizing Enterocolitis: manipulating the microbiome, part 2
The Newcastle, UK, group has published an article about the intestinal microbiome of babies receiving routine probiotic prophylaxis. Abdulkadir B, et al. Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome. Neonatology. 2016;109(4):239-47. The authors studied 7 … Continue reading
Necrotizing Enterocolitis: manipulating the microbiome, part 1
Some very interesting recent publications about NEC, so I will post a multi-part bumper posting. The first has just been published (in tomorrow’s Lancet) Warner BB, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective … Continue reading
Which Surfactant is best?
Singh N, et al. Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants. Cochrane database of systematic reviews (Online). 2015;12:CD010249. This is the sort of systematic review that I find really helpful. Some … Continue reading
Posted in Neonatal Research
Tagged BPD, mortality, Randomized Controlled Trials, surfactant treatment, Systematic Reviews
2 Comments
Blood pressures in very immature babies
One recent publication initially looked very interesting from the title, Vesoulis ZA, et al. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2015. Unfortunately the authors interpretation of ‘massive data’ is … Continue reading
Posted in Neonatal Research
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Unilateral DNR orders?
A paper from Mark Mercurio and colleagues has been making some waves. In it they address the question of unilateral DNAR orders (previously called Do Not Resuscitate DNR orders, but now often referred to, more accurately as Do Not Attempt … Continue reading
Posted in Neonatal Research
3 Comments
New achievements!
Neonatal research has now passed a total of 400,000 page views since it started, thanks to many people for their encouragement My researchgate profile now shows over 5,000 citations of articles I have authored, or co-authored. Sometimes when you publish … Continue reading
Posted in Neonatal Research
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Death of a twin, further resources.
I recently wrote about the work from Newcastle in the UK about supporting parents who lose one of a pair of twins during the perinatal period. Nick Embleton wrote a comment about that post noting that they now have put … Continue reading
Posted in Neonatal Research
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Follow up of the PREMILOC post
Further to my post about the PREMILOC trial of routine hydrocortisone supplementation in extremely preterm infants, I received an email response from Olivier Baud, who was generally in agreement with my comments, but doubts the validity of adding the data … Continue reading
Inhaled steroids to prevent BPD, another trial.
This time from Japan, Nakamura T, et al. Early inhaled steroid use in extremely low birthweight infants: a randomised controlled trial. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2016. 211 babies with a birth weight less than 1000 … Continue reading
Late surfactant supplementation
After the initial phase of surfactant deficiency of the very preterm infant, inhibition and destruction of surfactant are common, the inflammation of the oxygen exposed preterm lung is probably important in the pathophysiology of bronchopulmonary dysplasia, and the adverse effects … Continue reading
Posted in Neonatal Research
Tagged BPD, Randomized Controlled Trials, surfactant treatment
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Neonatal Research 