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Author Archives: Keith Barrington
Prolonging CPAP in the preterm to improve pulmonary outcomes
I wrote about this trial after last year’s PAS meeting, mentioning that it looked like a potential significant improvement in respiratory care of the preterm The full publication confirms that is a real possibility. McEvoy CT, et al. Extended Continuous … Continue reading
Posted in Neonatal Research
Tagged BPD, CPAP, long term outcomes, Randomized Controlled Trials
3 Comments
Neonatal Research Shorts : April 2025
I used to do a series of shorter posts called “weekly updates” but I ran out of steam and have concentrated on longer posts in recent years. The last couple of weeks, with clinical service, I have had less time … Continue reading
Early hydrocortisone in shock?
A few years ago, we published our experience with the use of hydrocortisone in newborn infants in septic shock (Altit G, et al. Corticosteroid Therapy in Neonatal Septic Shock-Do We Prevent Death? Am J Perinatol. 2018;35(2):146-51), like many such studies … Continue reading
Posted in Neonatal Research
Tagged hydrocortisone, Hypotension, mortality, Randomized Controlled Trials, Sepsis, Shock, steroids
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Is it a duck? Is it a mole? Platipus and Trial Design Innovations.
When the platypus was first captured, killed, skinned and the pelt sent to a zoologist in London, George Shaw in 1799, he thought he was being scammed. He tried to find the stitches that had been used to cobble together … Continue reading
Posted in Neonatal Research
Tagged caffeine, Randomized Controlled Trials, Research Design
3 Comments
A lower limit for restrictive transfusion strategies? Not directly neonatology…
Several trials of liberal versus more restrictive transfusion practices have been published, and overall, it seems that being very restrictive in transfusions has no negative impacts on clinical outcomes, and depending on the trial, some positive benefits of avoiding transfusion. … Continue reading
Bilirubin is Bad for the Brain! Who knew?
We have known for a very long time that bilirubin can cause an encephalopathy leading to acute and chronic clinical impacts, the most severe chronic impacts being kernicterus, a disabling movement disorder and nerve deafness. What seems to be the … Continue reading
Breast is Best; is Fresher Better?
A recurrent problem in the NICU is “bandwagon-jumping”. An intervention with some preliminary positive data, and a possible physiologic rationale is widely adopted and made part of QI bundles with little or no reliable evidence that it is either effective … Continue reading
Neurodevelopmental Impairment, who decides what it is?
I have written frequently about my concerns with “NDI” as an important measure of neonatal outcomes, indeed, it seems to be often thought of as if it were the only important measure. It has very often been included as part … Continue reading
Posted in Neonatal Research
1 Comment
Not neonatology: trip to Panama
Just back from a week in Panama, organised by “Wings“, mostly in Darién province at the extreme east of the country. A really amazing experience, with over 300 bird species seen, including just over 200 “lifers” for me. On my … Continue reading
Posted in Neonatal Research
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Term and Near-Term babies at Risk of Early Onset Sepsis: Best Practice?
Sepsis caused by organisms transmitted during, or shortly before, labour is relatively uncommon in higher income countries with GBS screening programs; the incidence is now around 0.3 cases per 1000 live births, but varies, it may be as high as … Continue reading
Posted in Neonatal Research
1 Comment
Neonatal Research 