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Author Archives: Keith Barrington
How much oxygen for the resuscitation of the preterm?
I like a good acronym, so my initial response to the new TORPIDO trial was very positive! TORPIDO 30/60 was a large multicentre RCT comparing initial FiO2 concentrations for resuscitation of the preterm infant (Oei JL, et al. Targeted Oxygen … Continue reading
Universal Neonatal Genome sequencing?
It is over 2 years since I posted about this issue, in the meantime there have been a number of new initiatives, and several review articles and opinion pieces. Including a JAMA, “research of the year” article”. I was triggered … Continue reading
Why doesn’t closing the PDA help preterm infants?
I have been continuing to think about this issue, so will subject you all to some of my thoughts. The large RCTs of medication for closure of the PDA show no benefit, and some evidence of harms, but we all … Continue reading
Should we ever close the PDA?
The latest large multicentre RCT has just been published. Laughon MM, et al. Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants. JAMA. 2025. In this trial, infants of 22 to 28 weeks GA were randomized at between … Continue reading
Posted in Neonatal Research
Tagged BPD, long term outcomes, mortality, PDA, Randomized Controlled Trials, Systematic Reviews
2 Comments
Is this article trustworthy?
There are many ways that an article in the medical literature may not be worthy of trust, and whose results may be unreliable. I remember one of my own trials, LACUNA, which was a pilot RCT of lactoferrin supplementation to … Continue reading
Posted in Neonatal Research
Tagged Ethics, Randomized Controlled Trials, Research Design, Systematic Reviews
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Hope for HIE
I was struck this morning by a new article in Pediatric Research a “Family Perspectives” written by the founder of the organisation that has the same name as the title of this post, “Hope for HIE“, Betsy Pilon (Pilon B. … Continue reading
Longer term outcomes after cooling
One of the numerous major advances in neonatology during my career has been the introduction of therapeutic hypothermia for infants with Hypoxic Ischemic Encephalopathy (HIE). Mortality is decreased, by about 25%, and long term morbidity among survivors is also decreased, … Continue reading
Face masks for resuscitation?
Blank DA, et al. Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial. Lancet Child Adolesc Health. 2025;9(10):715–23. An excellent acronym for this trial. Hopefully it … Continue reading
Beware articles written by AI
I subscribe to Google alerts, which sends me an email whenever the phrase “neonatal research” appears on a new website or a new post. I was interested, therefore to receive an alert about an article which, according the blog “Bioengineer.org”, … Continue reading
Neonatal Research Shorts : November 2025
Ybarra M, et al. Low-Grade Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Concomitant Preterm Brain Injuries: Neurodevelopmental Outcomes at 3 Years of Age. J Pediatr. 2025:114713. Previous studies of the long term outcome of infants with germinal matrix or low grade IVH … Continue reading
Neonatal Research 