Yearly Archives: 2012

Weekly Updates #12

Posted on 27 October 2012 by Keith Barrington

Welzing L, Oberthuer A, Junghaenel S, Harnischmacher U, Stützer H, Roth B: Remifentanil/midazolam versus fentanyl/midazolam for analgesia and sedation of mechanically ventilated neonates and young infants: a randomized controlled trial. Intensive Care Medicine 2012, 38(6):1017-1024. A small RCT (n=23) comparing … Continue reading →

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Glutamine supplementation, just when you thought it was solved…

Posted on 24 October 2012 by Keith Barrington

Glutamine is one of the most abundant amino acids in our bodies, but there is relatively little in TPN as it is poorly soluble. During the first few days of limited enteral nutrition preterm babies receive little glutamine from any … Continue reading →

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Tocolytics and Network meta-analysis

Posted on 22 October 2012 by Keith Barrington

What do you do if you want to know what is the best treatment for a condition, and treatment A and treatment B have both been compared to placebo, but have never been compared to each other in RCTs? If … Continue reading →

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Weekly Updates #11

Posted on 21 October 2012 by Keith Barrington

Back to mostly actual neonatology this week Kumral A, Tuzun F, Yesilirmak DC, Duman N, Ozkan H: Genetic basis of apnoea of prematurity and caffeine treatment response: Role of adenosine receptor polymorphisms. Acta Paediatrica 2012, 101(7):e299-e303. The paper suffers from … Continue reading →

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Early Detection of Sepsis in the NICU

Posted on 16 October 2012 by Keith Barrington

This came out before I started my blog, but think it is very important. I was reminded that I had never mentioned it on this blog when I met Joseph Randall Moorman at the airport on the way back from … Continue reading →

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Fiddling while the data burns

Posted on 15 October 2012 by Keith Barrington

Two recent articles highlight one of the adverse consequences of our fixation on p<0.05. It became common during the 20th century to state that if your statistical test shows that the results you found are unlikely to be due to … Continue reading →

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Weekly updates #10

Posted on 13 October 2012 by Keith Barrington

Vanderbilt DL, Schrager SM, Llanes A, Chmait RH: Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome. American Journal of Obstetrics and Gynecology 2012, 207(4):320.e321-320.e326. The authors followed children born after laser surgery, … Continue reading →

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The Benefits of Chocolate (not quite neonatology, but relevant in the middle of a night on call)

Posted on 12 October 2012 by Keith Barrington

A new publication in the Prestigious New England Journal of Medicine (that is how the news media always refer to it, I think they should change the abbreviation to PNEJM) Messerli FH: Chocolate consumption, cognitive function, and nobel laureates. New England Journal … Continue reading →

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Fresh! New! but not any better.

Posted on 11 October 2012 by Keith Barrington

A new multicenter RCT in preterm infants has just been published. The ARIPI trial which was led by Dean Fergusson from Ottawa and included our NICU as one of the sites (Christian Lachance was our local lead investigator and is … Continue reading →

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Probiotics: enough is enough

Posted on 9 October 2012 by Keith Barrington

At the EAPS meeting in Istanbul, the Proprems trial results were just presented. Now this has not yet been subject to full peer-review, but as a report of a large multicenter RCT it is not likely that their main findings … Continue reading →

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