Yet another small RCT of probiotics. This time 150 infants less than 1500 grams birth weight in an NICU in Mexico were randomized to a mixture of 4 different Lactobacilli and Bifidobacterium infantis or control. There was a reduction in NEC stage 2 or greater (6/75 vs 12/75) of about the same magnitude as all the other trials. They also had lower mortality, and no adverse effects.
Here is the funnel plot with the new new study added. I can only say it again, its time we stopped doing placebo controlled RCTs and focused on finding the best preparation, and the optimal dose and timing. RCTs in women at risk of preterm delivery are also a good idea.