Tag Archives: Randomized Controlled Trials

Delayed cord clamping or cord milking for the very preterm newborn… or both?

Posted on 18 May 2015 by Keith Barrington

What should we be doing, given the current state of the evidence, for the very preterm neonate? I think the evidence is now pretty clear that full-term babies have benefits, and no significant harm, from delayed cord clamping, which has … Continue reading →

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Neonatal Updates

Posted on 26 April 2015 by Keith Barrington

There’s been a lot of good stuff published recently, so time for a couple of Neonatal Updates. First the most recent (May) issue of the Archives Fetal and Neonatal edition was packed with interesting publications.(including 2 I have already blogged … Continue reading →

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Off-label NO: No… or Yes?

Posted on 8 April 2015 by Keith Barrington

Recent articles about off-label use of inhaled Nitric Oxide (iNO) in the preterm infant shows that such use is : a. extremely variable from one center to another, (Truog WE, et al. Inhaled nitric oxide usage in preterm infants in … Continue reading →

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What’s new in non-invasive respiratory support?

Posted on 1 April 2015 by Keith Barrington

A round-up of a few publications that have appeared over the last few months. Lampland AL et al: Bi-level CPAP does not improve gas exchange when compared with conventional CPAP for the treatment of neonates recovering from respiratory distress syndrome. … Continue reading →

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What is the news about probiotics?

Posted on 9 March 2015 by Keith Barrington

A few things have been happening recently: first of all, the big news was that Solgar recalled ABCDophilus as a result of some contamination of the product. As many of you will probably know, there was fungal contamination of the … Continue reading →

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Brain Food for Preterms

Posted on 18 November 2014 by Keith Barrington

All food is brain food when your brain is making 250,000 new neurones every minute. In a small two-center trial first published in 2013 50 very preterm babies were randomized to different parenteral nutritional intakes. The main differences between the groups … Continue reading →

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Neonatal Updates

Posted on 14 November 2014 by Keith Barrington

I haven’t done one of these for a while, getting too verbose I  guess, but here is a selection of interesting recent articles with just a few sentences about them. Mola-Schenzle E, Staffler A, Klemme M, Pellegrini F, Molinaro G, … Continue reading →

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Magnesium for brain protection and longer term outcomes.

Posted on 6 November 2014 by Keith Barrington

Two new articles describing the longer term follow up (to school age) of antenatal magnesium, when used for brain protection. 1. Doyle LW, Anderson PJ, Haslam R, Lee KJ, Crowther C, Australasian Collaborative Trial of Magnesium Sulphate Study G. School-age … Continue reading →

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What do parents of twins (and the twins) think about randomizing multiples

Posted on 31 October 2014 by Keith Barrington

There has been some controversy recently about how we should randomize twins (and triplets or more) in neonatal trials. The question being whether randomizing the babies independently or randomizing them as a group is preferable. Those who wish to randomize … Continue reading →

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Appropriate outcomes for neonatal research

Posted on 14 October 2014 by Keith Barrington

Neil Marlow has published a thoughtful, and thought provoking, article to address the issue outlined in the title. What are the appropriate outcomes when designing neonatal research studies? It has become almost a rule, that a multi-center trial of an … Continue reading →

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