Tag Archives: Gastro-oesophageal reflux

Spitting Up, it is normal

A new study in Pediatrics asked parents how they would feel about a hypothetical scenario. They gave a history of a patient who is spitting up, possiting, regurgitating or whatever you want to call it, and either gave it  a … Continue reading

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Erythromycin: not another toxic placebo!

Erythromycin is an antibiotic. This much is true. It is active against mycoplasma and against ureaplasmas, but is very poor at actually eradicating them. It also stimulates motilin receptors in the bowel, that is why it increases bowel activity, and … Continue reading

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More about reflux: anti-acid medications may also be toxic placebos

While I am still finalizing my long overdue chapter on gastro-esophageal reflux (sorry Sanjay if you are reading this, it is on its way, honestly) I have been reviewing the data on acid blockade as a potential treatment. Probably the … Continue reading

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Domperidone for GE reflux; toxic and worse than placebo!

As mentioned in a previous post, to get cisapride for a patient in Canada, you have to contact Health Canada for special permission through the Special Access Program. The last time that I am aware of someone asking Health Canada for special … Continue reading

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Cisapride for GE reflux; more toxic placebos!

I am currently writing a chapter for a textbook, the chapter will deal with GE reflux. So I have been reviewing the data around various treatment options. I have already written on this blog about the lack of physiologic rationale … Continue reading

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A toxic placebo

One very frequently used agent in the NICU is metoclopramide, prescribed almost exclusively for gastro-esophgeal reflux, (occasionally in an attempt to improve feeding tolerance). Let us assume for a moment that a baby does have clinical signs which are due to reflux, that … Continue reading

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