Category Archives: Neonatal Research

A toxic placebo

Posted on 8 July 2012 by Keith Barrington

One very frequently used agent in the NICU is metoclopramide, prescribed almost exclusively for gastro-esophgeal reflux, (occasionally in an attempt to improve feeding tolerance). Let us assume for a moment that a baby does have clinical signs which are due to reflux, that … Continue reading →

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Reducing transfusions in the NICU

Posted on 6 July 2012 by Keith Barrington

I don’t know why I didn’t think of this, but it is sort of obvious, it just takes someone to think about it and then do it. We need to reduce blood draws in preterm infants, the blood we take … Continue reading →

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Outcomes of GBS meningitis; as good as 24 week premies.

Posted on 4 July 2012 by Keith Barrington

As several of you may know, I am co-author, with Annie Janvier, of a series of articles examining how our prejudices about the worth of individuals affect decision making in the critically ill. In some of those articles we compare … Continue reading →

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Does the way we feed babies affect Necrotizing Enterocolitis?

Posted on 2 July 2012 by Keith Barrington

There is a widespread feeling that the method of introduction and advancement of feeds affects the frequency of necrotizing enterocolitis (known as NEC). Multiple observational studies have been published that seem to support this fear. However when we search for randomized controlled trials comparing feeding practices … Continue reading →

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What do babies die of in resource poor countries?

Posted on 28 June 2012 by Keith Barrington

Two very recent publications about neonatal mortality in resource poor countries. The first is from 6 different low resource countries and one medium resource country (Argentina) the authors presented the birth weight, gestational age and age at death of babies … Continue reading →

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What next for birth asphyxia?

Posted on 27 June 2012 by Keith Barrington

Now that therapeutic hypothermia has been proven effective and safe for infants with Hypoxic Ischemic Encephalopathy, one might ask what next? We still are not sure if it is of any value to cool infants after 6 hours of age, … Continue reading →

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Perinatal outcomes of IVF twins

Posted on 22 June 2012 by Keith Barrington

Another post about twins and IVF. I’ll back off soon, I promise. A systematic review published just last year notes that the outcomes of twins conceived after IVF is worse than those who are conceived naturally. (Rossi AC, D’Addario V. … Continue reading →

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Twins and triplets five times more likely to die within first year

Posted on 21 June 2012 by Keith Barrington

Twins and triplets five times more likely to die within first year | Society | The Guardian. To most of us in neonatology, this news item, published in the Guardian, based on data from the UK national database,  is no real surprise. … Continue reading →

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When to deliver twins?

Posted on 21 June 2012 by Keith Barrington

A new RCT from Australia randomized 235 mothers carrying twins to be either delivered at 37 weeks gestation, or allowed to continue for at least another week (Dodd J, Crowther C, Haslam R, Robinson J, for the Twins Timing of … Continue reading →

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What is heteroresistance?

Posted on 20 June 2012 by Keith Barrington

Recent cases of coagulase negative staphylococci, that were very difficult to eradicate, have led to an assessment of whether the phenomenon of heteroresistance may play a part. To be honest, for me this is entirely new; I was not aware … Continue reading →

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