Author Archives: Keith Barrington

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About Keith Barrington

I am a neonatologist and clinical researcher at Sainte Justine University Health Center in Montréal

NIDCAP, battling systematic reviews.

Posted on 7 January 2014 by Keith Barrington

I mentioned Arne Ohlsson’s review of the NIDCAP studies in a previous post. A new systematic review comes to different conclusions. This review (Fazilleau L, Parienti JJ, Bellot A, Guillois B: Nidcap in preterm infants and the neurodevelopmental effect in … Continue reading →

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Stem Cells for BPD, we might be getting there, but without the cells

Posted on 7 January 2014 by Keith Barrington

The development of this field has been fascinating, one of the most productive investigators has been Bernard Thébaud who has just written a very clear review article for non cell researchers in Pediatric Research with his colleague Moses Fung. (Fung … Continue reading →

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More than a diagnosis

Posted on 6 January 2014 by Keith Barrington

The latest from Annie Janvier and team, a publication describing the experiences of families in their internet support group questionnaire study. this particular publication is interested in what happened to families that had a prenatal diagnosis, of trisomy 13 or trisomy … Continue reading →

Posted in Advocating for impaired children | Tagged , | 18 Comments

Drug shortages

Posted on 18 December 2013 by Keith Barrington

The recent study by Kluckow and his colleagues points out another serious issue in neonatology: drug shortages. In recent times we have had poor or no supplies of dramatically important drugs, including for example indomethacin, phenobarbitone and more recently caffeine. We also … Continue reading →

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Long term outcomes after Very Extremely Preterm Delivery

Posted on 15 December 2013 by Keith Barrington

Another blog post suggested by a reader, this time from Jim Goodmar from San Diego. This study of neurological and developmental outcomes of babies born before 25 weeks is remarkable in a number of ways. (Herber-Jonat S, Streiftau S, Knauss … Continue reading →

Posted in Neonatal Research, The CPS antenatal counselling statement | Tagged , , , | 4 Comments

The PDA, indomethacin and pulmonary hemorrhages.

Posted on 15 December 2013 by Keith Barrington

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading →

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PDA shunts and extubation

Posted on 12 December 2013 by Keith Barrington

Following on from my recent post about PEEP levels and PDA shunts, this new article from Perth. The authors prospectively enrolled very immature infants (< 28 weeks) before a planned early extubation and did echocardiograms before and after. The mean … Continue reading →

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Omega 3 containing lipid emulsions for the preterm: time for a large RCT

Posted on 11 December 2013 by Keith Barrington

A recent small RCT from Turkey, n=80 (Beken S, Dilli D, Fettah ND, Kabatas EU, Zenciroglu A, Okumus N: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: A randomized controlled trial. Early … Continue reading →

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PEEP and ductal shunts

Posted on 9 December 2013 by Keith Barrington

I never thought that modest increase in PEEP would have a real effect on ductal shunting. As the size of the ductal shunt depends on the pressure gradient across the PDA and the resistance of the vessel, in order to … Continue reading →

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Acid suppression doesn’t work, and it’s not safe. pHunny how we got here.

Posted on 6 December 2013 by Keith Barrington

Maybe it’s not pHunny at all. A good quality review article about the use of acid blockade for treating what are sometimes called ‘symptoms of reflux’. Rosen R: Gastroesophageal reflux in infants: More than just a pHenomenon. JAMA Pediatrics 2013. … Continue reading →

Posted in Neonatal Research | Tagged | 4 Comments