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Author Archives: Keith Barrington
Neonatal Updates
Härkin P, et al. Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial. The Journal of pediatrics. 2016. Despite all the interest in paracetamol (acetaminophen in N America) for ductal closure, most of the published data so far … Continue reading
Posted in Neonatal Research
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Why didn’t erythropoietin improve the outcome of preterm babies?
Because that is the result of a newly published RCT of erythropoietin (EPO) for neuroprotection of small preterm babies, no effect. Natalucci G, et al. Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome … Continue reading
The microbiome of plastic tubes in children
Petersen SM, et al. Nasogastric feeding tubes from a neonatal department yield high concentrations of potentially pathogenic bacteria – even one day after insertion. Pediatr Res. 2016. These authors cultured 94 nasogastric feeding tubes from 34 preterm infants. 1 ml … Continue reading
Posted in Neonatal Research
Tagged infection control, Randomized Controlled Trials, Sepsis
2 Comments
Neonatal Updates
Raina A, et al. Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates. Acta Paediatrica. 2016. This was an RCT in 160 full-term babies with perinatal asphyxia and encephalopathy. Babies, who … Continue reading
How to define BPD
An article published at the end of 2015, (I only just got the full-text) compared 3 diagnostic criteria for defining BPD. The original 36 week threshold by Andy Shennan, the NIH workshop definition, and the ‘physiologic’ definition requiring a room-air … Continue reading
CMV transmission by breast milk in the very preterm, how important is it?
Over the past couple of years there have been quite a few articles addressing this issue, so I guess it must be important. The results of all these studies are not consistent, however, Kelly MS, et al. Postnatal Cytomegalovirus Infection … Continue reading
Is breast-milk really best?
Although many people (including myself) are convinced that human breast milk is the preferable nutrition for human babies, including the preterm, some of the evidence regarding benefits is shaky. For example the evidence that breast milk feeding reduces late-onset sepsis. … Continue reading
Posted in Neonatal Research
Tagged breast milk, Necrotising Enterocolitis, nutrition, Randomized Controlled Trials, Sepsis
6 Comments
The multidisciplinary conference, a parental view.
When patients are more complex than average, or there are multiple complications, or difficult ethical issues, we frequently organize “multidisciplinary conferences” which involve all the medical consultants and nursing, often also our social work and/or psychology personnel and the spiritual … Continue reading
Erythropoietin for Asphyxia
A preliminary RCT in babies undergoing therapeutic hypothermia (Wu YW, et al. High-dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016). They randomized 50 babies with HIE who were being cooled to 1000 units/kg on days 1,2,3,5, … Continue reading
Posted in Neonatal Research
Tagged asphyxia, Hypothermia, Randomized Controlled Trials
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Necrotizing Enterocolitis: manipulating the microbiome, part 3
Abdulkadir B, et al. Stool bacterial load in preterm infants with necrotising enterocolitis. Early Hum Dev. 2016;95:1-2. More work from the Newcastle group, this time the group decided not to look at the proportion of different bugs in the stools, … Continue reading
Neonatal Research 