Monthly Archives: November 2025

Is this article trustworthy?

Posted on 21 November 2025 by Keith Barrington

There are many ways that an article in the medical literature may not be worthy of trust, and whose results may be unreliable. I remember one of my own trials, LACUNA, which was a pilot RCT of lactoferrin supplementation to … Continue reading →

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Hope for HIE

Posted on 20 November 2025 by Keith Barrington

I was struck this morning by a new article in Pediatric Research a “Family Perspectives” written by the founder of the organisation that has the same name as the title of this post, “Hope for HIE“, Betsy Pilon (Pilon B. … Continue reading →

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Longer term outcomes after cooling

Posted on 13 November 2025 by Keith Barrington

One of the numerous major advances in neonatology during my career has been the introduction of therapeutic hypothermia for infants with Hypoxic Ischemic Encephalopathy (HIE). Mortality is decreased, by about 25%, and long term morbidity among survivors is also decreased, … Continue reading →

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Face masks for resuscitation?

Posted on 12 November 2025 by Keith Barrington

Blank DA, et al. Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial. Lancet Child Adolesc Health. 2025;9(10):715–23. An excellent acronym for this trial. Hopefully it … Continue reading →

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Beware articles written by AI

Posted on 11 November 2025 by Keith Barrington

I subscribe to Google alerts, which sends me an email whenever the phrase “neonatal research” appears on a new website or a new post. I was interested, therefore to receive an alert about an article which, according the blog “Bioengineer.org”, … Continue reading →

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Neonatal Research Shorts : November 2025

Posted on 10 November 2025 by Keith Barrington

Ybarra M, et al. Low-Grade Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Concomitant Preterm Brain Injuries: Neurodevelopmental Outcomes at 3 Years of Age. J Pediatr. 2025:114713. Previous studies of the long term outcome of infants with germinal matrix or low grade IVH … Continue reading →

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Clinical examination and treatment of septic shock. Not neonatology.

Posted on 7 November 2025 by Keith Barrington

Andromeda-Shock-2 Investigators for the Andromeda Research Network SSoAR, et al. Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA. 2025. This is a very interesting trial evaluating the usefulness of clinical assessment … Continue reading →

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Lactoferrin supplementation does not prevent late-onset sepsis in the preterm… or is it more complicated that that?

Posted on 6 November 2025 by Keith Barrington

Many of my readers will remember the impressive results of the high-quality study by Paolo Manzoni, Manzoni P, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA. 2009;302(13):1421–8) which showed that … Continue reading →

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Return to the Regression to the Mean

Posted on 5 November 2025 by Keith Barrington

After my post on regression to the mean, and its importance in studies of apnoea therapy, I was thinking of other examples. Some which have been most evident to me are those which impact on areas of medicine that I … Continue reading →

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Beware of meta-analysis factories

Posted on 4 November 2025 by Keith Barrington

I mentioned in my previous post, an issue with meta-analyses; there have been several I have read recently which are very problematic. They seem to be produced by groups that have little concern for the quality of their product. This … Continue reading →

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