Tag Archives: Randomized Controlled Trials

Face masks for resuscitation?

Posted on 12 November 2025 by Keith Barrington

Blank DA, et al. Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial. Lancet Child Adolesc Health. 2025;9(10):715–23. An excellent acronym for this trial. Hopefully it … Continue reading →

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Clinical examination and treatment of septic shock. Not neonatology.

Posted on 7 November 2025 by Keith Barrington

Andromeda-Shock-2 Investigators for the Andromeda Research Network SSoAR, et al. Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA. 2025. This is a very interesting trial evaluating the usefulness of clinical assessment … Continue reading →

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Lactoferrin supplementation does not prevent late-onset sepsis in the preterm… or is it more complicated that that?

Posted on 6 November 2025 by Keith Barrington

Many of my readers will remember the impressive results of the high-quality study by Paolo Manzoni, Manzoni P, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA. 2009;302(13):1421–8) which showed that … Continue reading →

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Return to the Regression to the Mean

Posted on 5 November 2025 by Keith Barrington

After my post on regression to the mean, and its importance in studies of apnoea therapy, I was thinking of other examples. Some which have been most evident to me are those which impact on areas of medicine that I … Continue reading →

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Beware of meta-analysis factories

Posted on 4 November 2025 by Keith Barrington

I mentioned in my previous post, an issue with meta-analyses; there have been several I have read recently which are very problematic. They seem to be produced by groups that have little concern for the quality of their product. This … Continue reading →

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Do blood transfusions treat apnoea of prematurity?

Posted on 3 November 2025 by Keith Barrington

There has for a long time been a thought that anemic babies with many apnoeas could benefit from a blood transfusion which would decrease their apnoeic spells. This idea has never been directly tested by an RCT. That is, a … Continue reading →

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Non-invasive high-frequency oscillation; worth the hassle?

Posted on 29 October 2025 by Keith Barrington

Non-invasive HFOV can be delivered by a variety of different equipment and interfaces. The high flows and upper airway turbulence probably have an impact on gas exchange; It appears that the effective dead space of the oro-nasopharynx is washed out … Continue reading →

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Avoiding IVs in moderately preterm babies

Posted on 28 October 2025 by Keith Barrington

A new very large (for neonatology) RCT has just been published. Ojha S, et al. Full exclusively enteral fluids from day 1 versus gradual feeding in preterm infants (FEED1): a open-label, parallel-group, multicentre, randomised, superiority trial. Lancet Child Adolesc Health. … Continue reading →

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Neonatal Research Shorts : October 2025

Posted on 2 October 2025 by Keith Barrington

Afifi J, et al. Atropine Versus Placebo for Neonatal Nonemergent Intubation: A Randomized Clinical Trial. J Pediatr. 2025;286:114719 I had thought this was a settled issue, Neil Finer showed many years ago that atropine alone decreased bradycardias during intubation. But … Continue reading →

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Caffeine is good for the preterm brain; might more caffeine be even better?

Posted on 24 September 2025 by Keith Barrington

One of the pivotal RCTs in neonatology was the CAP study (Schmidt B, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357(19):1893–902). We performed that study because there was no data on the … Continue reading →

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