Monthly Archives: February 2025

Early hydrocortisone in shock?

Posted on 21 February 2025 by Keith Barrington

A few years ago, we published our experience with the use of hydrocortisone in newborn infants in septic shock (Altit G, et al. Corticosteroid Therapy in Neonatal Septic Shock-Do We Prevent Death? Am J Perinatol. 2018;35(2):146-51), like many such studies … Continue reading →

Posted in Neonatal Research | Tagged , , , , , , | Leave a comment

Is it a duck? Is it a mole? Platipus and Trial Design Innovations.

Posted on 19 February 2025 by Keith Barrington

When the platypus was first captured, killed, skinned and the pelt sent to a zoologist in London, George Shaw in 1799, he thought he was being scammed. He tried to find the stitches that had been used to cobble together … Continue reading →

Posted in Neonatal Research | Tagged , , | 3 Comments

A lower limit for restrictive transfusion strategies? Not directly neonatology…

Posted on 9 February 2025 by Keith Barrington

Several trials of liberal versus more restrictive transfusion practices have been published, and overall, it seems that being very restrictive in transfusions has no negative impacts on clinical outcomes, and depending on the trial, some positive benefits of avoiding transfusion. … Continue reading →

Posted in Neonatal Research | Tagged , | Leave a comment

Bilirubin is Bad for the Brain! Who knew?

Posted on 4 February 2025 by Keith Barrington

We have known for a very long time that bilirubin can cause an encephalopathy leading to acute and chronic clinical impacts, the most severe chronic impacts being kernicterus, a disabling movement disorder and nerve deafness. What seems to be the … Continue reading →

Posted in Neonatal Research | Tagged , , , | 3 Comments