Tag Archives: Sepsis

Sniffing out lung injury

Apparently exhaled breath analysis can be used to detect a number of pulmonary and systemic diseases. As a medical student I was taught  about some of the classical clinical signs of certain diseases (such as diabetic ketoacidosis) which make the … Continue reading

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Position statements and overtreatment

A few years ago when I was chair of the Canadian Paediatric Society Fetus and Newborn Committee, we produced a statement about what to do with full term babies with risk factors for sepsis. Our recommendation was, to put it … Continue reading

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New Lactoferrin Data

Two new articles addressing effects of lactoferrin. Both used bovine lactoferrin (bLF), one was in humans, the other in piglets. In case you haven’t been following closely, lactoferrin is an iron transport protein that has multiple anti-infective properties, against bacteria, … Continue reading

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Hero: Not just for infections any more

Sullivan BA, Grice SM, Lake DE, Moorman JR, Fairchild KD. Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. The Journal of pediatrics. 2014. Monitoring for abnormal heart rate characteristics has previously been shown in a … Continue reading

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Something else that doesn’t work in sepsis; albumin

Another multi-center RCT in adults with severe sepsis or septic shock with a negative result. This time 1800 adults in 100 ICUs in Italy were randomized. Fluid boluses were either crystalloid or 20% albumin and crystalloid. Blood pressure was somewhat … Continue reading

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Zinc supplementation: should we be galvanized into action?

I wasn’t sure how many non native-English speakers would get that joke, and jokes are rarely improved by explaining them, so if you don’t get it, just keep on reading. Terrin G, Berni Canani R, Passariello A, Messina F, Conti … Continue reading

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Septic Shock; 3 negative trials

Three trials back to back in the PNEJM (that’s the prestigious New England Journal of Medicine for any new readers) in adults with septic shock are disappointing: Early Goal Directed Therapy has become a dogma in recent years; it even … Continue reading

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Cohort study of Probiotics in our NICU

Our article describing the results of introducing routine probiotic prophylaxis in our NICU has just become available on-line. Janvier A, Malo J, Barrington KJ: Cohort Study of Probiotics in a North American Neonatal Intensive Care Unit. The Journal of pediatrics … Continue reading

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Maybe CRPs are not CRaP? Not entirely convinced yet.

This is  a nicely done study, with interesting data, but I am not sure I agree 100% with the conclusions. Lots of newborn babies get antibiotics for suspected infection, they are usually stopped at 48 hours if the cultures are negative, … Continue reading

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Is cows milk just for cows?

A new publication from the trial funded by Prolacta looking at possible benefits of their donor-human-milk derived preparations. This time it is the other comparison from the registered trial. That is; mothers who did not plan to breast feed were approached to … Continue reading

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