Tag Archives: Sepsis

Something else that doesn’t work in sepsis; albumin

Another multi-center RCT in adults with severe sepsis or septic shock with a negative result. This time 1800 adults in 100 ICUs in Italy were randomized. Fluid boluses were either crystalloid or 20% albumin and crystalloid. Blood pressure was somewhat … Continue reading

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Zinc supplementation: should we be galvanized into action?

I wasn’t sure how many non native-English speakers would get that joke, and jokes are rarely improved by explaining them, so if you don’t get it, just keep on reading. Terrin G, Berni Canani R, Passariello A, Messina F, Conti … Continue reading

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Septic Shock; 3 negative trials

Three trials back to back in the PNEJM (that’s the prestigious New England Journal of Medicine for any new readers) in adults with septic shock are disappointing: Early Goal Directed Therapy has become a dogma in recent years; it even … Continue reading

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Cohort study of Probiotics in our NICU

Our article describing the results of introducing routine probiotic prophylaxis in our NICU has just become available on-line. Janvier A, Malo J, Barrington KJ: Cohort Study of Probiotics in a North American Neonatal Intensive Care Unit. The Journal of pediatrics … Continue reading

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Maybe CRPs are not CRaP? Not entirely convinced yet.

This is  a nicely done study, with interesting data, but I am not sure I agree 100% with the conclusions. Lots of newborn babies get antibiotics for suspected infection, they are usually stopped at 48 hours if the cultures are negative, … Continue reading

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Is cows milk just for cows?

A new publication from the trial funded by Prolacta looking at possible benefits of their donor-human-milk derived preparations. This time it is the other comparison from the registered trial. That is; mothers who did not plan to breast feed were approached to … Continue reading

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Susceptibility to Sepsis

It looks like those Toll-like receptors may indeed be important. I included a review article in a previous Neonatal Updates, which was nice introduction to these transmembrane receptors that are important in immune responses. A new article suggests that variants … Continue reading

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NICE! Or mostly so… treatment of early onset neonatal infection

The National Institute of Clinical Excellence in the UK has been a real boon to the NHS, despite attempts to limits its influence by the pharmaceutical companies, the explicit evaluation of risks and benefits of various interventions allows appropriate use … Continue reading

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Early Detection of Sepsis in the NICU

This came out before I started my blog, but think it is very important. I was reminded that I had never mentioned it on this blog when I met Joseph Randall Moorman at the airport on the way back from … Continue reading

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What is heteroresistance?

Recent cases of coagulase negative staphylococci, that were very difficult to eradicate, have led to an assessment of whether the phenomenon of heteroresistance may play a part. To be honest, for me this is entirely new; I was not aware … Continue reading

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