Tag Archives: Sepsis

Sense about Sepsis

Recent guidelines regarding the evaluation and treatment of early onset sepsis, or the baby who has risk factors, have been widely criticized. Especially by me! And by me! The AAP for example recommends antibiotic treatment for all infants born after … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Should we all be wearing gloves? Every time we touch a baby?

Two new articles over the summer suggest that the answer to that question may well be yes. The first is the best quality of the studies, an RCT in a single center in the USA. Kaufman DA, Blackman A, Conaway MR, Sinkin … Continue reading

Posted in Neonatal Research | Tagged , , | 2 Comments

Sniffing out lung injury

Apparently exhaled breath analysis can be used to detect a number of pulmonary and systemic diseases. As a medical student I was taught  about some of the classical clinical signs of certain diseases (such as diabetic ketoacidosis) which make the … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Position statements and overtreatment

A few years ago when I was chair of the Canadian Paediatric Society Fetus and Newborn Committee, we produced a statement about what to do with full term babies with risk factors for sepsis. Our recommendation was, to put it … Continue reading

Posted in Neonatal Research | Tagged , | 1 Comment

New Lactoferrin Data

Two new articles addressing effects of lactoferrin. Both used bovine lactoferrin (bLF), one was in humans, the other in piglets. In case you haven’t been following closely, lactoferrin is an iron transport protein that has multiple anti-infective properties, against bacteria, … Continue reading

Posted in Neonatal Research | Tagged , , | 1 Comment

Hero: Not just for infections any more

Sullivan BA, Grice SM, Lake DE, Moorman JR, Fairchild KD. Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. The Journal of pediatrics. 2014. Monitoring for abnormal heart rate characteristics has previously been shown in a … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Something else that doesn’t work in sepsis; albumin

Another multi-center RCT in adults with severe sepsis or septic shock with a negative result. This time 1800 adults in 100 ICUs in Italy were randomized. Fluid boluses were either crystalloid or 20% albumin and crystalloid. Blood pressure was somewhat … Continue reading

Posted in Neonatal Research | Tagged , , | Leave a comment