Tag Archives: Retinopathy of Prematurity

Poietins for the brain?

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading

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Oxygen, transfusions, and NEC

What causes NEC! The answer is ‘who knows?’, or perhaps a better one would be ‘its complicated…’ You probably need an immature gut, gut mucosal injury, inflammation and cytokine release, and an abnormal microbiome, all of which probably interact in … Continue reading

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Public citizen are becoming a public danger

Public citizen are at it again, they have written another letter to the director of the DHHSS to try and follow up on their previous nonsense. I didn’t write about this when I first heard about it, as 1. it … Continue reading

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Insulin, nutrition, insulin-like growth factors and the retina

I’d really like to see a good quality review article with that title, there are several that touch on these issues (for example, here and here), but I find the data hard to digest, probably because it is relatively novel … Continue reading

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Omega 3 containing lipid emulsions for the preterm: time for a large RCT

A recent small RCT from Turkey, n=80 (Beken S, Dilli D, Fettah ND, Kabatas EU, Zenciroglu A, Okumus N: The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: A randomized controlled trial. Early … Continue reading

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Informed consent in the NICU

I have watched most of the presentations at the OHRP meeting, so you don’t have to. Many of the critics of SUPPORT make the same mistaken assumption, that usual care in the NICU is to individualize oxygen saturation targets, I … Continue reading

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What are the responsibilities of clinical researchers?

One of the presentations at the OHRP hearings of the HHS was by George Annas, a JD who has an MPH (for those outside of north america that means he is a lawyer, but with a masters in public health). … Continue reading

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Pre-SUPPORT, what did we really know?

One of the misplaced criticisms that have been made about the SUPPORT trial and the consent forms was that we should have known before the trial that there would be a difference in mortality, and that there would be a … Continue reading

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EPO, re-introducing confusion

I thought that routine erythropoietin (EPO) treatment of preterm infants had been thrown out of the window. It is well known that EPO levels are low in preterms after birth, which is part of the multifactorial pathophysiology of anaemia of … Continue reading

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SUPPORT: even better than originally thought

Public Citizen are at it again, repeating and expanding their idiotic criticisms of the SUPPORT trial. And stating that the trial was ‘even worse than originally thought’. They are now focusing on the ‘problem’ that the NICUs used ‘intentionally inaccurate’ … Continue reading

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