Tag Archives: Retinopathy of Prematurity

Retinopathy: up or down?

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading

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Neonatal Updates

Gschließer A, et al. Inter-expert and Intra-expert Agreement on the Diagnosis and Treatment of Retinopathy of Prematurity. American Journal of Ophthalmology. 2015;160(3):553-60.e3. The investigators showed 52 retinal photographs to 7 expert ophthalmologists, and then 8 weeks later showed them to … Continue reading

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NICUs are working better: still room for improvement.

As NICUs have become more effective, any proportional incremental improvements will necessarily get smaller, so larger and larger datasets will be needed to show any trends. The NICHD has just published data about survival and major acute morbidities among extremely … Continue reading

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Oxygen is good for you

Of course you can have too much of a good thing, but you should also try and stay above the minimum. The COT trial investigators, led by Christian Poets, have published a secondary analysis of the results, examining in particular … Continue reading

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Bevacizumab or that other more expensive one?

A very interesting and depressing group of articles in today’s BMJ. Retinopathy of prematurity is a small market compared to wet macular degeneration in the elderly, in whom VEGF inhibitors are proven to be extremely effective. Ranibizumab (I will call … Continue reading

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Should we be using bevacizumab for retinopathy of prematurity?

 Geloneck MM, Cet al: Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial. JAMA Ophthalmol 2014, 132(11):1327-1333. In this follow-up of the BEAT-RoP trial, eyes randomized to have laser were more likely to have severe … Continue reading

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Poietins for the brain?

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading

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