Tag Archives: Randomized Controlled Trials

Brain Food for Preterms

All food is brain food when your brain is making 250,000 new neurones every minute. In a small two-center trial first published in 2013 50 very preterm babies were randomized to different parenteral nutritional intakes. The main differences between the groups … Continue reading

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Neonatal Updates

I haven’t done one of these for a while, getting too verbose I  guess, but here is a selection of interesting recent articles with just a few sentences about them. Mola-Schenzle E, Staffler A, Klemme M, Pellegrini F, Molinaro G, … Continue reading

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Magnesium for brain protection and longer term outcomes.

Two new articles describing the longer term follow up (to school age) of antenatal magnesium, when used for brain protection. 1. Doyle LW, Anderson PJ, Haslam R, Lee KJ, Crowther C, Australasian Collaborative Trial of Magnesium Sulphate Study G. School-age … Continue reading

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What do parents of twins (and the twins) think about randomizing multiples

There has been some controversy recently about how we should randomize twins (and triplets or more) in neonatal trials. The question being whether randomizing the babies independently or randomizing them as a group is preferable. Those who wish to randomize … Continue reading

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Appropriate outcomes for neonatal research

Neil Marlow has published a thoughtful, and thought provoking, article to address the issue outlined in the title. What are the appropriate outcomes when designing neonatal research studies? It has become almost a rule, that a multi-center trial of an … Continue reading

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Probiotics: so what about those ELBW babies?

After a comment to my previous post about probiotics, I wanted to clarify what I said about the ELBW baby, that is, the newborn with a birth weight below 1001 grams. It is true that there are few studies that … Continue reading

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The Time for a Confirmative Necrotizing Enterocolitis Probiotics Prevention Trial in the Extremely Low Birth Weight Infant in North America Is Well Past

What on earth are these people waiting for? A number of authors from Toronto and elsewhere have written a ridiculous editorial (entitled ‘The Time for a Confirmative Necrotizing Enterocolitis Probiotics Prevention Trial in the Extremely Low Birth Weight Infant in … Continue reading

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