Tag Archives: Randomized Controlled Trials

Should we all be wearing gloves? Every time we touch a baby?

Two new articles over the summer suggest that the answer to that question may well be yes. The first is the best quality of the studies, an RCT in a single center in the USA. Kaufman DA, Blackman A, Conaway MR, Sinkin … Continue reading

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What to give before intubation

The blog has been quiet recently, for various personal and professional reasons, but I will be getting back into the groove. I got really concerned over the last couple of days, my usually reliable personal PubNeoMed in my brain told … Continue reading

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New Lactoferrin Data

Two new articles addressing effects of lactoferrin. Both used bovine lactoferrin (bLF), one was in humans, the other in piglets. In case you haven’t been following closely, lactoferrin is an iron transport protein that has multiple anti-infective properties, against bacteria, … Continue reading

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Probiotics in preterm infants: not just for NEC prevention any more

A new RCT in more mature preterm infants 32 to 37 weeks compared the incidence of viral respiratory infections during the first year of life between infants who received prebiotics (galacto-oligosaccharide and polydextrose) probiotics (lactobacillus rhamnosus) or placebo between the … Continue reading

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Poietins for the brain?

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading

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Funny shaped heads? You can take the helmet off now.

I often see kids around my hospital wearing orthotic helmets, designed to make their heads more round (some of them ex-preterms), and I often wondered if they really work. A new RCT from the Netherlands shows no effect . Renske MvW, Leo … Continue reading

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Prophylactic fluconazole works; but we shouldn’t use it?

A new high quality multicenter RCT examined the effects of fluconazole prophylaxis in about 360 very tiny babies (VTB), that is they weighed less than 750g at birth. They were enrolled in the first 5 days of life to fluconazole … Continue reading

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