Tag Archives: Randomized Controlled Trials

The death knell for Xenon?

Azzopardi D, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2016;15(2):145-53.  Babies who undergo therapeutic hypothermia for perinatal encephalopathy … Continue reading

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Surfactant without intubation, where are we?

A recent trial from Germany tried to answer the question of whether giving surfactant through a thin catheter while the baby was on CPAP would reduce “death or BPD” compared to intubation for surfactant. Kribs A, et al. Nonintubated Surfactant Application … Continue reading

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When to deliver after Preterm Ruptured Membranes

I have often wondered why my obstetrical colleagues would often induce labour once a woman with ruptured membranes reached 34 weeks. I wasn’t aware of any data to support doing this, or, on the other hand, any good data to … Continue reading

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The best outcome variable for very preterm newborns?

Death or ‘neurodevelopmental impairment’ (NDI) as a combined outcome has become a sort of de facto standard as the primary outcome for neonatal clinical trials. Because many very preterm infants have developmental delay, intellectual and learning difficulties, and some have … Continue reading

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The last nail in the coffin of permissive hypercapnia?

Thome UH, et al. Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. Lancet Respir Med. 2015;3(7):534-43. This German multi-center trial randomized infants 400 to 1000 g birth weight to 2 different CO2 target ranges. The … Continue reading

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Retinopathy: up or down?

The oxygen saturation targeting trials showed more retinopathy with higher oxygen saturation targets. Will this translate into more retinopathy in actual practice? Many units have increased their saturation targets as a result of those studies. This may indeed lead to … Continue reading

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Late Surfactant may not be effective, probably.

A large multi-center trial (n=511) led by Roberta Ballard has just been published. (Ballard RA, et al. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr 2015.) In this trial infants had similar … Continue reading

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