Tag Archives: PDA

Paracetamol for the PDA? Maybe not, this time.

Roofthooft DW, et al. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015:1-8. In contrast to the previous study that I blogged … Continue reading

Posted in Neonatal Research | Tagged | 1 Comment

Paracetamol for the PDA?

EL-Khuffash A, et al. Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2015;100(3):F253-F6. (CoI statement: The authors of this paper are friends, colleagues and collaborators of mine), the … Continue reading

Posted in Neonatal Research | Tagged | 1 Comment

Reassuring Prophylactic Indomethacin Data

One of Annie Janvier’s first research projects was a case control study of the influence of prophylactic indomethacin on intestinal perforations. Under my supervision she analyzed cases of spontaneous intestinal perforation (SIP), and we analyzed the influence of prophylactic indomethacin, … Continue reading

Posted in Neonatal Research | Tagged , | Leave a comment

Can Paracetamol (acetaminophen) close the ductus arteriosus?

A new publication by Afif El-Khuffash and his colleagues (El-Khuffash A et al. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res. 2014;76(3):238-44) describes a retrospective review of paracetamol use in newborn … Continue reading

Posted in Neonatal Research | Tagged | Leave a comment

Low Cardiac Output after PDA ligation

Some babies after PDA ligation develop a low cardiac output, Patrick McNamara and his colleagues have defined that as being less than 200 mL/kg/min left ventricular output. This cohort study of 30 infants post-ligation, by Afif El-Khuffash and colleagues at … Continue reading

Posted in Neonatal Research | Tagged , | 1 Comment

The PDA, indomethacin and pulmonary hemorrhages.

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading

Posted in Neonatal Research | Tagged , , , | 1 Comment

PDA shunts and extubation

Following on from my recent post about PEEP levels and PDA shunts, this new article from Perth. The authors prospectively enrolled very immature infants (< 28 weeks) before a planned early extubation and did echocardiograms before and after. The mean … Continue reading

Posted in Neonatal Research | Tagged , | 2 Comments