Tag Archives: Necrotising Enterocolitis

Probiotics work in Germany also

A new study from the German Neonatal Network Database compares the incidence of NEC between centers that used probiotics, centers that did not use probiotics, and centers that changed their practice part way through the data collection period from being … Continue reading

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New Lactoferrin Data

Two new articles addressing effects of lactoferrin. Both used bovine lactoferrin (bLF), one was in humans, the other in piglets. In case you haven’t been following closely, lactoferrin is an iron transport protein that has multiple anti-infective properties, against bacteria, … Continue reading

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Hero: Not just for infections any more

Sullivan BA, Grice SM, Lake DE, Moorman JR, Fairchild KD. Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. The Journal of pediatrics. 2014. Monitoring for abnormal heart rate characteristics has previously been shown in a … Continue reading

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Necrotising Enterocolitis: is abdominal ultrasound helpful?

I am still not convinced. (Maybe I could ask, and answer, the same thing about abdominal radiography!) In recent years in my practice we have had examples of echographic diagnosis of intramural gas in stable infants who had an abdominal … Continue reading

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Probiotics: what do parents want?

Some day, I might slow down with the probiotics posts, but not right now! A letter published in Archives reports the results of a parent survey. In the 3 NICUs implicated probiotics are given with parental information and an ‘opt-out’ … Continue reading

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Zinc supplementation: should we be galvanized into action?

I wasn’t sure how many non native-English speakers would get that joke, and jokes are rarely improved by explaining them, so if you don’t get it, just keep on reading. Terrin G, Berni Canani R, Passariello A, Messina F, Conti … Continue reading

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Bugs and Breast Milk

Neonatology recently published a commentary asking the following question about routine probiotic supplementation, ‘what will it take to change practice?‘ This was immediately followed by another commentary, from Neena Modi, explaining why she is still reluctant. Although I have a … Continue reading

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Oxygen, transfusions, and NEC

What causes NEC! The answer is ‘who knows?’, or perhaps a better one would be ‘its complicated…’ You probably need an immature gut, gut mucosal injury, inflammation and cytokine release, and an abnormal microbiome, all of which probably interact in … Continue reading

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Transfusion Associated Necrotizing EnteroColitis?

I’m still not absolutely sure about TANEC, as it now seems to be called. It is certainly possible that transfusions could trigger gut injury in very preterm babies, but how to prove it? Even if the temporal association was absolutely … Continue reading

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Stop the Antibiotics!

We know that prolonged antibiotic use in preterm babies increase their chance of later developing NEC. The assumption being that the disturbance of the intestinal flora leads to the increase in susceptibility. Here is some more direct evidence to support … Continue reading

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