Tag Archives: long term outcomes

Inhaled Nitric Oxide in Preterms

Kinsella JP, Cutter GR, Steinhorn RH, Nelin LD, Walsh WF, Finer NN, et al. Noninvasive Inhaled Nitric Oxide Does Not Prevent Bronchopulmonary Dysplasia in Premature Newborns. The Journal of pediatrics. 2014. My Cochrane review (which is in the process of being … Continue reading

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Poietins for the brain?

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading

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Prophylactic fluconazole works; but we shouldn’t use it?

A new high quality multicenter RCT examined the effects of fluconazole prophylaxis in about 360 very tiny babies (VTB), that is they weighed less than 750g at birth. They were enrolled in the first 5 days of life to fluconazole … Continue reading

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High Frequency Ventilation and long term pulmonary outcomes

The UK Oscillation study (UKOS) was a large multicenter trial in the UK of high-frequency compared to conventional ventilation; 800 babies <29 weeks gestation were randomized, if they were intubated from birth and were less than 1 hour old, to … Continue reading

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Executive Function?

Raju TNK, Mercer BM, Burchfield DJ, Joseph GF. Periviable birth: executive summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Society for Maternal-Fetal Medicine, American Academy of Pediatrics, and American College … Continue reading

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Retraction of a systematic review

Exactly when should an article be retracted? That is not so easy a question to answer, fraud and significant data or image manipulation are one fairly obvious group of reasons. Making errors and/or poor research design are more tricky. When … Continue reading

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More from SUPPORT, not research governance and consent this time!

One of the difficulties in performing neonatal research is how to determine the most clinically appropriate outcomes. Bronchopulmonary dysplasia is often used as a dichotomous outcome variable, partly to facilitate the design of research, including combining it with other competing outcomes, … Continue reading

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