Tag Archives: long term outcomes

Neonatal Updates

I haven’t done one of these for a while, getting too verbose I  guess, but here is a selection of interesting recent articles with just a few sentences about them. Mola-Schenzle E, Staffler A, Klemme M, Pellegrini F, Molinaro G, … Continue reading

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Magnesium for brain protection and longer term outcomes.

Two new articles describing the longer term follow up (to school age) of antenatal magnesium, when used for brain protection. 1. Doyle LW, Anderson PJ, Haslam R, Lee KJ, Crowther C, Australasian Collaborative Trial of Magnesium Sulphate Study G. School-age … Continue reading

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Appropriate outcomes for neonatal research

Neil Marlow has published a thoughtful, and thought provoking, article to address the issue outlined in the title. What are the appropriate outcomes when designing neonatal research studies? It has become almost a rule, that a multi-center trial of an … Continue reading

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Inhaled Nitric Oxide in Preterms

Kinsella JP, Cutter GR, Steinhorn RH, Nelin LD, Walsh WF, Finer NN, et al. Noninvasive Inhaled Nitric Oxide Does Not Prevent Bronchopulmonary Dysplasia in Premature Newborns. The Journal of pediatrics. 2014. My Cochrane review (which is in the process of being … Continue reading

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Poietins for the brain?

Ohls RK, Kamath-Rayne BD, Christensen RD, Wiedmeier SE, Rosenberg A, Fuller J, et al. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo. Pediatrics. 2014. I’ve written about this trial before, a smallish 3 arm trial of erythropoietin, … Continue reading

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Prophylactic fluconazole works; but we shouldn’t use it?

A new high quality multicenter RCT examined the effects of fluconazole prophylaxis in about 360 very tiny babies (VTB), that is they weighed less than 750g at birth. They were enrolled in the first 5 days of life to fluconazole … Continue reading

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High Frequency Ventilation and long term pulmonary outcomes

The UK Oscillation study (UKOS) was a large multicenter trial in the UK of high-frequency compared to conventional ventilation; 800 babies <29 weeks gestation were randomized, if they were intubated from birth and were less than 1 hour old, to … Continue reading

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