Tag Archives: Gastro-oesophageal reflux

Neonatal Updates

Deshmukh M, et al. Effect of gastric lavage on feeding in neonates born through meconium-stained liquor: a systematic review. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2015. When I first went to one of the hospitals I … Continue reading

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Acid suppression doesn’t work, and it’s not safe. pHunny how we got here.

Maybe it’s not pHunny at all. A good quality review article about the use of acid blockade for treating what are sometimes called ‘symptoms of reflux’. Rosen R: Gastroesophageal reflux in infants: More than just a pHenomenon. JAMA Pediatrics 2013. … Continue reading

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GE Reflux… again

Esomeprazole is one of the Proton pump inhibitors that is quite effective at reducing gastric acid production. This RCT of 51 infants (preterms to 1 month of age) randomized babies that had symptoms that were interpreted as being due to … Continue reading

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Spitting Up, it is normal

A new study in Pediatrics asked parents how they would feel about a hypothetical scenario. They gave a history of a patient who is spitting up, possiting, regurgitating or whatever you want to call it, and either gave it  a … Continue reading

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Erythromycin: not another toxic placebo!

Erythromycin is an antibiotic. This much is true. It is active against mycoplasma and against ureaplasmas, but is very poor at actually eradicating them. It also stimulates motilin receptors in the bowel, that is why it increases bowel activity, and … Continue reading

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More about reflux: anti-acid medications may also be toxic placebos

While I am still finalizing my long overdue chapter on gastro-esophageal reflux (sorry Sanjay if you are reading this, it is on its way, honestly) I have been reviewing the data on acid blockade as a potential treatment. Probably the … Continue reading

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Domperidone for GE reflux; toxic and worse than placebo!

As mentioned in a previous post, to get cisapride for a patient in Canada, you have to contact Health Canada for special permission through the Special Access Program. The last time that I am aware of someone asking Health Canada for special … Continue reading

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