Tag Archives: BPD

More from SUPPORT, not research governance and consent this time!

One of the difficulties in performing neonatal research is how to determine the most clinically appropriate outcomes. Bronchopulmonary dysplasia is often used as a dichotomous outcome variable, partly to facilitate the design of research, including combining it with other competing outcomes, … Continue reading

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Stem Cells for BPD, we might be getting there, but without the cells

The development of this field has been fascinating, one of the most productive investigators has been Bernard Thébaud who has just written a very clear review article for non cell researchers in Pediatric Research with his colleague Moses Fung. (Fung … Continue reading

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The PDA, indomethacin and pulmonary hemorrhages.

In a comment on a recent post, Martin Kluckow pointed out that they have just had published a moderately sized RCT. It was supposed to be larger, but intravenous indomethacin became unavailable, so they had to stop the trial. (Kluckow … Continue reading

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Reducing BPD by Avoiding Intubation

Sometimes more than one article gets published almost simultaneously on the same topic, sometimes with similar methodology. Two systematic reviews of the effects of trying to avoid or curtail endotracheal intubation in order to protect the lungs have just been … Continue reading

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High Flow Nasal Cannulae; finally learning about them

The Melbourne group must get fed up of publishing important research, here is another in the PNEJM. Manley BJ, Owen LS, Doyle LW, Andersen CC, Cartwright DW, Pritchard MA, Donath SM, Davis PG: High-flow nasal cannulae in very preterm infants … Continue reading

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Who should get surfactant?

I think the literature is clear, if you need surfactant, the earlier you get it the better. If you don’t need surfactant you are better off never being intubated. So how do we decide? Current management protocols usually put babies … Continue reading

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Acidosis and the preterm, effects on heart and lungs

Noori S, Wu T-W, Seri I. pH Effects on Cardiac Function and Systemic Vascular Resistance in Preterm Infants. The Journal of pediatrics. 2013;162(5):958-63.e1. This study examined the effects of pH on ventricular outputs and calculated vascular resistance. There was little … Continue reading

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How long is a piece of string? When is a PDA hemodynamically significant?

The answer to the first question is traditionally ‘twice as long as half a piece of string’ which is supposed to be funny. Equally difficult is the second question, when is a patent ductus arteriosus (PDA)  hemodynamically significant? We could … Continue reading

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Supporting oxygen limits

The initial results of the SUPPORT trial examining the effects of different oxygen limits stopped a lot of us in our tracks. We started these trials because most of us thought that aiming for lower oxygen saturation targets would reduce … Continue reading

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Trying to improve outcomes of preterm infants

Two recent RCTs in high risk newborns of things I would never have thought of. The first is a trial of Estradiol and Progesterone supplementation (Trotter A, Steinmacher J, Kron M, Pohlandt F. Neurodevelopmental Follow-Up at Five Years Corrected Age … Continue reading

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