Tag Archives: asphyxia

Neonatal Updates : Therapeutic hypothermia

Three recent articles dealing with the effects of therapeutic hypothermia: Drury PP, Gunn ER, Bennet L, Gunn AJ. Mechanisms of Hypothermic Neuroprotection. Clin Perinatol. 2014;41(1):161-75. the first is an excellent review article describing how hypothermia works, SPOILER ALERT, its mostly … Continue reading

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Time is Brain

That phrase, which has been used to denote the urgency of early stroke treatment in adults, has been purloined by Marianne Thoresen and her colleagues for their article about the importance of timely hypothermia treatment, and now by me for … Continue reading

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HIE: what’s next?

Kapadia VS, Chalak LF, Dupont TL, Rollins NK, Brion LP, Wyckoff MH: Perinatal Asphyxia with Hyperoxemia within the First Hour of Life Is Associated with Moderate to Severe Hypoxic-Ischemic Encephalopathy. The Journal of pediatrics 2013. If you are acidotic at … Continue reading

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What do babies die of in resource poor countries?

Two very recent publications about neonatal mortality in resource poor countries. The first is from 6 different low resource countries and one medium resource country (Argentina) the authors presented the birth weight, gestational age and age at death of babies … Continue reading

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What next for birth asphyxia?

Now that therapeutic hypothermia has been proven effective and safe for infants with Hypoxic Ischemic Encephalopathy, one might ask what next? We still are not sure if it is of any value to cool infants after 6 hours of age, … Continue reading

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Long Term outcomes after Therapeutic Hypothermia for HIE

Two new publications from multicenter trials of hypothermia as a treatment for post-asphyxial encephalopathy. The first from the NICHD network, and the whole body cooling study led by Seetha Shankaran. They examined the children and performed IQ testing at 6 to 7 … Continue reading

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15,000,000 preterm babies a year

A new report from the World Health Organisation highlights the importance of prematurity as a major health problem around the world. http://www.who.int/pmnch/media/news/2012/preterm_birth_report/en/index.html Fifteen million babies are born prematurely in the world each year, and the number is increasing everywhere. You can use … Continue reading

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Encephalopathy and induced hypothermia

The widespread use of therapeutic hypothermia for infants with encephalopathy has raised several questions. Prior to this new(ish) technique, the neurological examination of the infant was thought to have a reasonably good predictive accuracy for long term outcomes. Infants who were never … Continue reading

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Hypocapnia in asphyxiated infants

Some of my posts are not necessarily going to be about very new publications, sometimes a clinical event or question stimulates me to review the literature, and I will share my findings with the readers. Spontaneous hypocapnia is not rare … Continue reading

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